赣南医科大学学报2024，Vol.44Issue(10)：981-987,1004,8.DOI:10.3969/j.issn.1001-5779.2024.10.001
调控动脉粥样硬化泡沫细胞形成的信号通路研究进展
Research progress of pivotal signaling pathways governing foam cell formation during atherosclerosis
摘要
Abstract
Atherosclerosis is a prevalent chronic inflammatory disease seen in the cardiovascular and cerebrovascular systems,and acts as the primary cause of cardiovascular diseases such as coronary heart disease and stroke.This disease turns to occur in population carrying dyslipidemia,hypertension,and smoking habits.Early symptoms are not obvious and the prognosis is poor.In the pathogenesis of atherosclerosis,the formation and accumulation of foam cells derived from mononuclear macrophages and vascular wall smooth muscle cells are crucial for lesion development.Investigating the molecular mechanisms that regulate foam cell formation holds significant importance in understanding atherosclerosis pathogenesis and identifying new treatment targets.Lipid metabolic disorders,lipid phagocytosis dysfunction,inflammatory responses,and abnormal cell apoptosis are listed as common reasons which promote cell foaming.However,the upstream regulatory signaling network controlling these cellular responses remains to be unclear.This article reviews pivotal signaling pathways which play crucial roles in foam cell formation and their detailed mechanisms,mostly by summarizing the promoting or inhibiting effect of pathways including PI3K/AKT,MAPK,AMPK,NF-κB and PPARγ/LXRα on lipid metabolism,lipid phagocytosis,inflammatory responses and cell apoptosis,and thus illustrated the interaction between upstream signaling ways and downstream cellular responses.Meanwhile,a list of potential pharmaceutical ingredients which display anti-atherosclerosis effects by affecting above signaling pathways during foam cell formation is summed up.Overall,this review provides a summary of the upstream and downstream effects and interactions of various signaling pathways involved in the generation of foam cells,with the hope of constructing a molecular regulatory network during foam cell formation,and providing a theoretical basis for clinical treatment of atherosclerosis.关键词
动脉粥样硬化/泡沫细胞/信号通路/单核巨噬细胞/血管平滑肌细胞Key words
Atherosclerosis/Foam cells/Signaling pathways/Mononuclear macrophage/Vascular smooth muscle cell分类
医药卫生引用本文复制引用
刘晓炎,涂世进,周娟,甘滔..调控动脉粥样硬化泡沫细胞形成的信号通路研究进展[J].赣南医科大学学报,2024,44(10):981-987,1004,8.基金项目
国家自然科学基金项目(31960201,32160218) （31960201,32160218）
赣南医学院校级科技创新团队课题(TD201903) （TD201903）
