赣南医科大学学报2024，Vol.44Issue(10)：988-992,1042,6.DOI:10.3969/j.issn.1001-5779.2024.10.002
外侧缰核及其神经环路在重度抑郁症中的作用
The role of the lateral habenula nucleus and its neural circuit in major depressive disorder
摘要
Abstract
Major depressive disorder(MDD)is a prevalent emotional disorder,with its incidence rate showing an annual increase.The lateral habenula(LHb),situated in the epithalamus,plays a role in encoding negative emotions such as fear,anxiety,and depression.Research indicates that abnormal activity in the LHb is closely related to the onset and development of MDD,making it a significant brain region in MDD research.This article provides a brief overview of the cellular architecture,fiber connections,and related neural circuit mechanisms of the LHb in MDD.A review of the literature reveals that the LHb mediates depression-related neural circuits,including the lateral habenula-ventral tegmental area,dorsal raphe nucleus-lateral habenula,ventral pallidum-lateral habenula,lateral hypothalamic area-lateral habenula,substantia innominata-lateral habenula,medial prefrontal cortex-lateral habenula,and ventral tegmental area-lateral habenula.This provides new insights and targets for understanding the pathogenesis of MDD and the development of new therapeutic drugs.关键词
重度抑郁症/外侧缰核/神经环路Key words
Major depressive disorder/Lateral habenula/Neural circuit分类
医药卫生引用本文复制引用
赵国建,齐月,张子炜,杨梅,黄志华,唐晓璐..外侧缰核及其神经环路在重度抑郁症中的作用[J].赣南医科大学学报,2024,44(10):988-992,1042,6.基金项目
江西省自然科学基金面上项目(20224BAB206035) （20224BAB206035）
江西省自然科学基金青年一般项目(20202BABL216082) （20202BABL216082）
