赣南医科大学学报2024，Vol.44Issue(10)：1058-1063,6.DOI:10.3969/j.issn.1001-5779.2024.10.016
基于脂肪干细胞的软骨组织工程的研究新进展
New research progress of cartilage tissue engineering based on adipose stem cells
摘要
Abstract
The repair of cartilage defects has been a clinical challenge.In recent years,many significant advances have been achieved in cartilage tissue engineering using adipose-derived stem cells(ASCs)as seed cells,providing an exciting new method for cartilage repair.However,it is not mature yet.We reviewed the latest research progress and existing problems in cartilage tissue engineering involving ASCs,related cytokines,and various novel biomimetic scaffolds by referring to domestic and foreign literature in this article.The results of literature review show that ASCs possess many advantages such as abundant sources and low immunogenicity,especially the ability to differentiate into chondrocytes,making them be the promising seed cells for cartilage tissue engineering.Recent studies have found that related cytokines,particularly various extracellular vesicles and exosomes(containing many kinds of non-coding RNAs)secreted by ASCs can promote the cartilage differentiation of ASCs and inhibit the apoptosis of chondrocytes.Additionally,significant progress has been made in the research and development of scaffolds for cartilage tissue engineering in recent years,including 3D printing scaffolds,the nanomaterials scaffolds of graphene oxide(GO),and the composite biomimetic scaffolds constructed from various natural and synthetic materials and so on.However,there are still many challenges to be addressed.The future research in cartilage tissue engineering will focus on further improving the chondrogenic differentiation efficiency of ASCs and developing 3D biomimetic scaffolds that are more suitable for the microenvironment in vivo.关键词
脂肪干细胞/软骨组织工程/支架材料/胞间信号肽类和蛋白质类Key words
Adipose stem cells/Cartilage tissue engineering/Scaffold materials/Intercellular signal peptides and proteins分类
医药卫生引用本文复制引用
赖凌勇,徐房添,张亚梁,缪圣旺,周波..基于脂肪干细胞的软骨组织工程的研究新进展[J].赣南医科大学学报,2024,44(10):1058-1063,6.基金项目
国家自然科学基金项目(82260433) （82260433）
