经济动物学报2024，Vol.28Issue(4)：326-332,7.DOI:10.13326/j.jea.2024.1693
哈蟆油水提物对环磷酰胺诱导的卵巢早衰小鼠的保护作用
Protective Effect of Water Extract from Rana Oviduct on Mouse Model of Premature Ovarian Failure Induced by Cyclophosphamide
摘要
Abstract
In order to explore the effect of Rana oviduct on ovarian function,42 eight-week-old female Kunming mice were selected in this experiment and randomly divided into six groups,namely blank control group,estrogen group,model group,pre-protection control group,positive control group and pre-protection group,seven mice in each group.The mice were fed by gavage for the first 14 days,and the mice were intraperitoneally injected for the next 14 days to create a model of premature ovarian failure.The test results showed that compared with the model group,the uterine index and ovarian index of the positive control group and the pre-protection group increased(P＜0.05),and the pre-protection group was more higher than those of the positive control group.Cyclophosphamide could significantly increase the serum levels of follicle-stimulating hormone,luteinizing hormone,testosterone,and prolactin(P＜0.05),estradiol,anti-Mullerian hormone and progesterone.The content of estradiol,anti-mullerian hormone and progesterone in the serum of the mice in the pre-protection group was significantly lower than that in the model group(P＜0.05).The serum levels of follicle-stimulating hormone,luteinizing hormone,testosterone,and prolactin were significantly lower than those in the model group(P＜0.05).Compared with the positive control group,the pre-protection group could significantly reduce serum luteinizing hormone,and compared with the model group,both the pre-protection group and the positive control group could significantly increase the serum anti-Mullerian hormone content(P＜0.05).The results show that Rana oviduct has a certain protective effect on mice with premature ovarian failure induced by cyclophosphamide.关键词
哈蟆油水提物/卵巢早衰/环磷酰胺/保护作用Key words
water extract from Rana oviduct/premature ovarian failure/cyclophosphamide/pro-tective effect分类
农业科技引用本文复制引用
张舒童,衣岩,刘舒欣,吴旻,卫功庆..哈蟆油水提物对环磷酰胺诱导的卵巢早衰小鼠的保护作用[J].经济动物学报,2024,28(4):326-332,7.基金项目
吉林省科技发展计划重点项目(20190304005YY) （20190304005YY）
