净水技术2024，Vol.43Issue(z2)：246-251,307,7.DOI:10.15890/j.cnki.jsjs.2024.s2.034
固相萃取-高效液相色谱-串联质谱法测定生活饮用水中11种全氟化合物的方法探究及应用
Exploration and Application of 11 Determination Perfluorinated Compounds in Domestic Drinking Water Using Solid-Phase Extraction Ultra-High Performance Liquid Chroma-tography Tandem Mass Spectrometry
摘要
Abstract
Solid-phase extraction high-performance liquid chromatography tandem mass spectrometry(SPE-HPLC-MS)for determining 11 perfluorinated compounds(PFCs)in domestic drinking water was established in this paper.After the sample was extracted by WAX solid phase extraction column,it was concentrated and directly sent to the liquid chromatography-mass spectrometer for analysis.It was separated by ZORBAX SB Aq chromatographic column(2.1 mm×100 mm,3.5 μm).The mobile phase was 5 mmol/L ammonium acetate solution-methanol for gradient elution.The electrospray AJS ion source negative ion(ESI-)mode scanning and multi reaction monitoring mode(MRM)were used for detection.The results showed that the linear relationships of 11 PFCs were good,within the linear range from 5.0 ng/L to 200 ng/L(r=0.998 4～0.999 8),with a detection limit from 0.32 ng/L to 1.20 ng/L.The recovery rates of 11 PFCs at three spiking levels of low,medium,and high for actual samples of drinking water were from 80.8％to 104.0％,from 84.1％to 102.0％,and from 86.9％to 123.0％,respectively,with a relative standard deviation(RSD)from 0.8％to 11.0％.This detection method has the advantages of simple operation and high sensitivity,it achieves the simultaneous determination of 11 PFCs by a conventional HPLC-MS mothod and meets the limit values of Standards for Drinking Water Quality(GB 5749-2022).It is suitable for the detection of PFCs in drinking water.关键词
生活饮用水/固相萃取/液质联用/全氟化合物(PFCs)/方法探究Key words
domestic drinking water/solid phase extraction/liquid chromatography-mass spectrometry/perfluorinated compounds(PFCs)/method exploration分类
医药卫生引用本文复制引用
张琪雨,吴艳龙,张祥汉,曾志鹏,胡颖斌..固相萃取-高效液相色谱-串联质谱法测定生活饮用水中11种全氟化合物的方法探究及应用[J].净水技术,2024,43(z2):246-251,307,7.基金项目
广东省自然科学基金项目(2021A1515010365) （2021A1515010365）
