实用临床医药杂志2024，Vol.28Issue(19)：16-21,6.DOI:10.7619/jcmp.20241131
血清人神经趋化蛋白及人甲壳质酶蛋白40水平与老年阿尔茨海默症患者早期认知功能损害的关系
Relationships of serum human fractalkine and chitinase-3-like protein 1 levels with early cognitive impairment in elderly patients with Alzheimer's disease
摘要
Abstract
Objective To investigate the relationships of serum levels of human fractalkine(CX3CL1)and chitinase-3-like protein 1(YKL-40)with early cognitive impairment in elderly patients with Alzheimer's disease(AD).Methods A total of 110 AD patients in the Second Affiliated Hospital of Xinxiang Medical University from February 2021 to December 2023 were selected as AD group,and 50 healthy individuals with physical examination during the same period were selected as control group.Clinical materials and serum levels of CX3CL1 and YKL-40 were compared between the two groups,and multivariate Logistic regression models were used to analyze the influencing factors of cognitive im-pairment in AD patients.Based on the Mini-Mental State Examination(MMSE)score,the 110 AD patients were divided into mild cognitive impairment group(n=47),moderate cognitive impairment group(n=36),and severe cognitive impairment group(n=27).Spearman correlation analysis was performed to explore the relationships of serum CX3CL1 and YKL-40 with MMSE score,Addenbro-oke's Cognitive Examination-Ⅲ(ACE-Ⅲ)score,and Montreal Cognitive Assessment(MoCA)score.Results The AD group had higher proportions of patients aged over 80 years,with an edu-cation level of primary school or below,smoking history,alcohol consumption history,diabetes mel-litus,hypertension,AD family history,and living alone as well as higher serum levels of CX3CL1 and YKL-40 compared to the control group;conversely,the AD group had a lower proportion of pa-tients engaging in no physical exercise/labor,and lower MMSE,ACE-Ⅲ,and MoCA scores,with significant between-group differences(P＜0.05).Advanced age,diabetes mellitus,and high ser-um levels of CX3CL1 and YKL-40 were independent risk factors for cognitive impairment in AD pa-tients(P＜0.05),while an education level of college or above was a protective factor(P＜0.05).Compared with the mild cognitive impairment group,the moderate and severe cognitive impairment groups had higher serum levels of CX3 CL1 and YKL-40,and the severe cognitive impairment group had higher serum levels of CX3 CL1 and YKL-40 than the moderate group,with significant between-group differences(P＜0.05).Spearman correlation analysis revealed that serum CX3CL1 and YKL-40 were negatively correlated with MMSE,ACE-Ⅲ,and MoCA scores(P＜0.05).Conclu-sion Serum CX3CL1 and YKL-40 are highly expressed in elderly AD patients,and are closely re-lated to early cognitive impairment in elderly AD patients.关键词
阿尔茨海默症/血清人神经趋化蛋白/人甲壳质酶蛋白40/认知障碍Key words
Alzheimer's disease/serum human fractalkine/chitinase-3-like protein 1/cog-nitive impairment分类
医药卫生引用本文复制引用
潘飞,许彤,张景丹,赵峥,李亚迪,徐亚南,徐亚辉..血清人神经趋化蛋白及人甲壳质酶蛋白40水平与老年阿尔茨海默症患者早期认知功能损害的关系[J].实用临床医药杂志,2024,28(19):16-21,6.基金项目
河南省医学科技攻关计划(联合共建)项目(LHGJ20190481) （联合共建）
