实用临床医药杂志2024，Vol.28Issue(19)：27-32,6.DOI:10.7619/jcmp.20241289
伴快速眼动期睡眠行为障碍帕金森病患者的睡眠结构及其与认知功能、抑郁状态、运动功能的相关性
Sleep structure of Parkinson's disease patients with rapid eye movement sleep behavior disorder and its correlations with cognitive function,depressive state and motor function
摘要
Abstract
Objective To investigate the sleep structure of Parkinson's disease(PD)patients with rapid eye movement sleep behavior disorder(RBD)and its correlations with cognitive function,depressive state and motor function.Methods A total of 120 PD patients were enrolled in this stud-y,and divided into PD+RBD group(n=45)and PD group(n=75)based on the presence or ab-sence of RBD.Sleep structure was recorded for both groups.The scores of the Montreal Cognitive As-sessment(MoCA),Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD),Uni-fied Parkinson's Disease Rating Scale Part Ⅲ(UPDRS-Ⅲ)and Scales for Outcomes in Parkinson's Disease-Autonomic(SCOPA-AUT)were compared between the two groups.The correlations of Mo-CA,HAMA,HAMD,UPDRS-Ⅲ and SCOPA-AUT scores with sleep structure in the PD+RBD group were analyzed.Results The PD+RBD group showed significantly higher percentage of non-rapideye movement(NREM)at stage 1,arousal index,periodic limb movements during sleep(PLMS)and ap-nea-hypopnea index(AHI)compared to the PD group,while the percentages of NREM at stage 3,rap-id eye movement(REM)sleep,sleep efficiency and lowest oxygen saturation were significantly lower(P＜0.05).The PD+RBD group also had significantly higher HAMA,HAMD,UPDRS-Ⅲ and SCOPA-AUT scores,and significantly lower MoCA scores compared to the PD group(P＜0.05).In the PD+RBD group,the percentages of NREM at stage 1,arousal index,PLMS and AHI were positively correlated with HAMA,HAMD,UPDRS-Ⅲ and SCOPA-AUT scores,and negatively cor-related with MoCA scores(P＜0.05).Conversely,the percentages of NREM at stage 3,REM sleep,sleep efficiency and lowest oxygen saturation were negatively correlated with HAMA,HAMD,UPDRS-Ⅲ and SCOPA-AUT scores,and positively correlated with MoCA scores(P＜0.05).Con-clusion PD patients with RBD exhibit disrupted sleep structure,which is closely associated with cognitive function,depressive state,motor function,and autonomic nervous system function.关键词
快速眼动期睡眠行为障碍/帕金森病/睡眠结构/认知功能/非快速眼动Key words
rapid eye movement sleep behavior disorder/parkinson's disease/sleep struc-ture/cognitive function/non-rapid eye movement分类
医药卫生引用本文复制引用
姬亚杰,刘海林,张许平,蔡卫卫,尹变利,段智慧..伴快速眼动期睡眠行为障碍帕金森病患者的睡眠结构及其与认知功能、抑郁状态、运动功能的相关性[J].实用临床医药杂志,2024,28(19):27-32,6.基金项目
2023年度河南省医学科技攻关计划项目(LHGJ20230810) （LHGJ20230810）
2022年度河南省医学科技攻关计划项目(LHGJ20220944) （LHGJ20220944）
