伴快速眼动期睡眠行为障碍帕金森病患者的睡眠结构及其与认知功能、抑郁状态、运动功能的相关性OACSTPCD

Objective To investigate the sleep structure of Parkinson's disease(PD)patients with rapid eye movement sleep behavior disorder(RBD)and its correlations with cognitive function,depressive state and motor function.Methods A total of 120 PD patients were enrolled in this stud-y,and divided into PD+RBD group(n=45)and PD group(n=75)based on the presence or ab-sence of RBD.Sleep structure was recorded for both groups.The scores of the Montreal Cognitive As-sessment(MoCA),Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD),Uni-fied Parkinson's Disease Rating Scale Part Ⅲ(UPDRS-Ⅲ)and Scales for Outcomes in Parkinson's Disease-Autonomic(SCOPA-AUT)were compared between the two groups.The correlations of Mo-CA,HAMA,HAMD,UPDRS-Ⅲ and SCOPA-AUT scores with sleep structure in the PD+RBD group were analyzed.Results The PD+RBD group showed significantly higher percentage of non-rapideye movement(NREM)at stage 1,arousal index,periodic limb movements during sleep(PLMS)and ap-nea-hypopnea index(AHI)compared to the PD group,while the percentages of NREM at stage 3,rap-id eye movement(REM)sleep,sleep efficiency and lowest oxygen saturation were significantly lower(P＜0.05).The PD+RBD group also had significantly higher HAMA,HAMD,UPDRS-Ⅲ and SCOPA-AUT scores,and significantly lower MoCA scores compared to the PD group(P＜0.05).In the PD+RBD group,the percentages of NREM at stage 1,arousal index,PLMS and AHI were positively correlated with HAMA,HAMD,UPDRS-Ⅲ and SCOPA-AUT scores,and negatively cor-related with MoCA scores(P＜0.05).Conversely,the percentages of NREM at stage 3,REM sleep,sleep efficiency and lowest oxygen saturation were negatively correlated with HAMA,HAMD,UPDRS-Ⅲ and SCOPA-AUT scores,and positively correlated with MoCA scores(P＜0.05).Con-clusion PD patients with RBD exhibit disrupted sleep structure,which is closely associated with cognitive function,depressive state,motor function,and autonomic nervous system function.