实用临床医药杂志2024，Vol.28Issue(19)：118-122,5.DOI:10.7619/jcmp.20241444
血钙、25-羟维生素D及尿酸水平与良性阵发性位置性眩晕的相关性研究
Correlations of serum calcium,25-hydroxyvitamin D and uric acid levels with benign paroxysmal positional vertigo
摘要
Abstract
Objective To investigate the correlations of serum calcium,25-hydroxyvitamin D and uric acid levels with benign paroxysmal positional vertigo(BPPV).Methods A total of 96 pa-tients with BPPV were enrolled in vertigo group and further divided into mild vertigo(30 cases),moderate vertigo(42 cases),and severe vertigo(24 cases)groups based on the severity of vertigo symptoms.Additionally,63 healthy people undergoing physical examination without BPPV were re-cruited as control group.Serum calcium,25-hydroxyvitamin D,and uric acid levels were compared among groups,and their correlations with the severity of vertigo in BPPV patients were analyzed.Fol-low-up was conducted for 3 months to record the recurrence rate of BPPV.Results The serum calci-um and 25-hydroxyvitamin D levels in the moderate and severe vertigo groups were significantly lower,while uric acid levels,total score of Dizziness Handicap Inventory(DHI)as well as functional,emo-tional,and physical scores were significantly higher than those in the mild vertigo group and control group(P＜0.05).Moreover,the severe vertigo group exhibited lower serum calcium and 25-hydroxyvitamin D levels and higher uric acid level,DHI total score and functional,emotional,as well as physical scores(P＜0.05).No significant differences were observed in serum calcium,25-hydroxyvitamin D,uric acid levels,or DHI scores between the mild vertigo group and the control group(P＞0.05).The severity of vertigo in BPPV patients was negatively correlated with serum calcium(r=-0.557,P＜0.05)and 25-hydroxyvitamin D levels(r=-0.467,P＜0.05),and positively correlated with uric acid levels(r=0.504,P＜0.05).The 3-month recurrence rate of BPPV was 8.33％(8/96).Compared to patients with serum calcium ≥2.11 mmol/L,25-hydroxyvitamin D ≥30 ng/mL,and uric acid ≤428 μmol/L,those with serum calcium＜2.11 mmol/L,25-hydroxyvitamin D＜30 ng/mL,and uric acid＞428 μmol/L had significantly higher BPPV recurrence rates(P＜0.05).Conclu-sion BPPV patients exhibit abnormally lower serum calcium and 25-hydroxyvitamin D levels and abnormally higher uric acid levels.The severity of vertigo in BPPV patients is negatively correlated with serum calcium and 25-hydroxyvitamin D levels and positively correlated with uric acid levels.关键词
血钙/25-羟维生素D/尿酸/良性阵发性位置性眩晕/复发Key words
serum calcium/25-hydroxyvitamin D/uric acid/benign paroxysmal positional vertigo/recurrence分类
医药卫生引用本文复制引用
相明飞,刘莹莹,余明杰..血钙、25-羟维生素D及尿酸水平与良性阵发性位置性眩晕的相关性研究[J].实用临床医药杂志,2024,28(19):118-122,5.基金项目
中国红十字基金会"医学赋能-领航精英科研项目"(XM_HR_YXFN_2021_05_24) （XM_HR_YXFN_2021_05_24）
