实用临床医药杂志2024，Vol.28Issue(20)：1-5,5.DOI:10.7619/jcmp.20242084
乳腺癌患者4种不同指标变化及其与病理参数的关系
Changes in four different indicators and their relationships with pathological parameters in breast cancer patients
摘要
Abstract
Objective To analyze the changes in the ratio of helper T cell 17 to regulatory T cells(Th17/Treg),serum ferritin(SF),microRNA-145(miR-145),and microRNA-132(miR-132)levels in breast cancer patients and their relationships with pathological parameters.Methods A to-tal of 92 breast cancer patients from January 2022 to December 2023 were enrolled as study group,and 105 patients with benign breast diseases during the same period were selected as control group.Changes in SF,miR-132,Th17/Treg,and miR-145 were compared between the two groups,and the diagnostic value of these indicators for breast cancer was analyzed.Results Compared with the con-trol group,the study group had higher peripheral blood Th17/Treg and serum SF levels,and lower serum miR-145 and miR-132 expression levels(P＜0.05).Patients with tumor diameters＞2 cm,clinical stages of Ⅲ to Ⅳ,moderately or poorly differentiated tumors,and lymph node metastasis had lower serum miR-145 and miR-132 expression levels than those with tumor diameters ≤2 cm,clinical stages of Ⅰ to Ⅱ,highly differentiated tumor,and no lymph node metastasis(P＜0.05).Compared with patients with clinical stages of Ⅰ to Ⅱ,highly differentiated tumors,and no lymph node metas-tasis,those with clinical stages of Ⅲ to Ⅳ,moderately or poorly differentiated tumors,and lymph node metastasis had higher serum SF levels(P＜0.05).Patients with lymph node metastasis had higher Th17/Treg levels than those without(P＜0.05).The area under the curve(AUC)for combined detection of Th17/Treg,SF,miR-145,and miR-132 levels in breast cancer patients was higher than that for individual detection(P＜0.05),with higher sensitivity and specificity.Conclusion Th17/Treg,SF,miR-145,and miR-132 are abnormally expressed in the blood of breast cancer patients and are correlated with their pathological parameters.Combined detection of these four indicators has higher value in the clinical diagnosis of breast cancer.关键词
乳腺癌/辅助性T细胞17/调节性T细胞/铁蛋白/微小核糖核酸-145/微小核糖核酸-132/病理参数Key words
breast cancer/helper T cell 17/regulatory T cell/ferritin/microRNA-145/mi-croRNA-132/pathological parameters分类
医药卫生引用本文复制引用
汪倩倩,董雨萍,严丽洁,王水..乳腺癌患者4种不同指标变化及其与病理参数的关系[J].实用临床医药杂志,2024,28(20):1-5,5.基金项目
国家自然科学基金项目(82172683) （82172683）
