实用临床医药杂志2024，Vol.28Issue(20)：12-17,6.DOI:10.7619/jcmp.20233927
预后营养指数和改良格拉斯哥预后评分与宫颈癌患者预后的关系
Correlations of prognostic nutritional index and modified Glasgow prognostic score with prognosis in patients with cervical cancer
摘要
Abstract
Objective To investigate the prognostic value of prognostic nutritional index(PNI)and modified Glasgow prognostic score(mGPS)in patients with cervical cancer.Methods A total of 120 patients with cervical cancer were selected as the study subjects.Patients'data were collected and analyzed,with follow-up conducted until June 30,2023.Kaplan-Meier method was used to plot sur-vival curves.Log-rank test and Cox regression analysis were employed to identify prognostic factors.Results The median follow-up time for patients in this study was 61 months,with a median survival time of 52 months.During the follow-up period,41 patients(34.17％)died.The 3-year and 5-year survival rates were 82.50％and 66.67％,respectively.Receiver operating characteristic(ROC)curves showed that the areas under the curve(AUC)for PNI,mGPS,albumin(ALB),lymphocytes(LYM),C-reactive protein(CRP),and neutrophils(NEU)in predicting patient prognosis were 0.90,0.81,0.84,0.86,0.82,and 0.71,respectively.The optimal cutoff values were determined to be 41.80 for PNI,0.50 points for mGPS,34.25 g/L for ALB,1.44 × 109/L for LYM,5.45 × 109/L for CRP and 7.25 mg/L for NEU.Cox regression analysis indicated that PNI(HR=4.18,95％CI=2.83 to 9.21,P=0.015),mGPS[HR=1.95,95％CI=1.37 to 3.59,P＜0.001(mGPS=1 point);HR=3.07,95％CI=2.38 to 5.36,P＜0.001(mGPS=2 points)]and International Federation of Gynecology and Obstetrics(FIGO)staging[HR=2.03,95％CI=1.34 to 3.85,P=0.030(FIGO stage=stage Ⅲ);HR=3.46,95％CI=2.15 to 6.62,P=0.003(FIGO stage=stage Ⅳ)]were significant risk factors affecting the prognosis of cervical cancer patients.Conclusion PNI,mGPS and FIGO staging are important predictors of prognosis in cervical cancer patients.Attention to PNI and mGPS before treatment may help improve clinical outcomes.关键词
预后营养指数/改良格拉斯哥预后评分/宫颈肿瘤/生存时间/预后Key words
prognostic nutritional index/modified Glasgow prognostic score/cervical neo-plasms/survival time/prognosis分类
医药卫生引用本文复制引用
黄小丽,黄笑燕,宋淑慧,张英..预后营养指数和改良格拉斯哥预后评分与宫颈癌患者预后的关系[J].实用临床医药杂志,2024,28(20):12-17,6.基金项目
江西省上饶市科学技术研发项目(2020SRS010) （2020SRS010）
