实用临床医药杂志2024，Vol.28Issue(20)：27-31,5.DOI:10.7619/jcmp.20241855
5-氨基酮戊酸光动力疗法联合人干扰素α-2β治疗尖锐湿疣的效果分析
Efficacy of 5-Aminolaevulinic acid photodynamic therapy combined with human interferon α-2β in the treatment of condyloma acuminatum
摘要
Abstract
Objective To investigate the therapeutic effects of 5-Aminolaevulinic acid photody-namic therapy(ALA-PDT)combined with human interferon α-2β in the treatment of condyloma acu-minatum(CA)and its impacts on serum T-cell subsets,chemokine ligand 19(CCL19),and matrix metalloproteinase-3(MMP-3)levels.Methods A total of 86 patients with CA were enrolled and ran-domly divided to control group(treated with ALA-PDT alone)and observation group(treated with ALA-PDT combined with human interferon α-2β),with 43 patients in each group.Clinical efficacy,changes in serum T-cell subsets,CCL19,and MMP-3 levels before and after treatment were compared between the two groups.Adverse reactions during treatment were recorded.Patients were followed up for 6 months to record the number of warts and recurrence rate.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P＜0.05).After treatment,the levels of CD4+,CD8+,and CD4+/CD8+in the observation group were signifi-cantly elevated compared to the control group(P＜0.05).Additionally,serum CCL19 levels in-creased,while MMP-3 levels decreased in the observation group post-treatment compared to the control group(P＜0.05).No significant difference was observed in the incidence of adverse reactions be-tween the two groups(P＞0.05).The recurrence rate and the number of average recurrent warts were significantly higher in the control group than in the observation group(P＜0.05).Conclusion The combination of ALA-PDT and human interferon α-2 β exhibits remarkable efficacy in the treatment of CA,which can effectively regulate serum T-cell subset levels,reduce MMP-3 levels,enhance CCL19 levels,and demonstrates good safety.关键词
5-氨基酮戊酸光动力疗法/人干扰素α-2β/尖锐湿疣/趋化因子配体19/基质金属蛋白酶-3Key words
5-Aminolevulinic acid photodynamic therapy/human interferon α-2β/condylo-ma acuminatum/chemokine ligand 19/matrix metalloproteinase-3分类
医药卫生引用本文复制引用
方宇辉,王馨依,李坤鹏,王伟..5-氨基酮戊酸光动力疗法联合人干扰素α-2β治疗尖锐湿疣的效果分析[J].实用临床医药杂志,2024,28(20):27-31,5.基金项目
安徽省重点研发计划项目(2022SF-0162) （2022SF-0162）
