实用临床医药杂志2024，Vol.28Issue(20)：60-65,6.DOI:10.7619/jcmp.20242397
妊娠期糖尿病患者血清分泌性卷曲相关蛋白-5、热休克蛋白60、溶质载体家族16成员11的表达及其与胰岛素抵抗的关系
Expression levels of serum secreted frizzled-related protein 5,heat shock protein 60 and solute carrier family 16 member 11 in patients with gestational diabetes mellitus and their relationships with insulin resistance
摘要
Abstract
Objective To investigate the expression levels of secreted frizzled-related protein 5(sFRP5),heat shock protein 60(HSP60)and solute carrier family 16 member 11(SLC16A11)in serum of patients with gestational diabetes mellitus(GDM)and their relationships with insulin resist-ance.Methods A total of 120 GDM patients in the hospital from January 2022 to December 2023 were selected as study group,and another 120 healthy pregnant women in the same period were se-lected as control group.The expression levels of serum sFRP5,HSP60 and SLC16A11 were detected;the levels of insulin resistance-related indicators[fasting blood glucose(FBG),fasting insulin(FINS),and homeostasis model assessment of insulin resistance(HOMA-IR)]were measured and calculated;the Pearson's correlation method was used to analyze the correlations of serum sFRP5,HSP60 and SLC16A11 with insulin resistance;the Logistic regression andysis and receiver operating characteristic(ROC)curve analysis were used to assess the relationships of serum sFRP5,HSP60 and SLC16A11 with GDM.Results The serum sFRP5 expression in the study group was signifi-cantly lower than that in the control group,while the serum HSP60,SLC16A11,FBG,FINS and HOMA-IR levels were significantly higher than those in the control group(P＜0.05).Pearson's correlation analysis showed that serum sFRP5 was negatively correlated with HSP60,SLC16A11,FBG,FINS and HOMA-IR(P＜0.05);serum HSP60 was positively correlated with SLC16A11,FBG,FINS and HOMA-IR(P＜0.05);serum SLC16A11 was positively correlated with FBG,FINS and HOMA-IR(P＜0.05).Multivariate Logistic regression analysis revealed that HSP60,SLC16A11,FBG,FINS and HOMA-IR were risk factors for GDM in pregnant patients,while sFRP5 was a protective factor(P＜0.05).The area under the curve(AUC)for the combined diagnosis of GDM in pregnant patients by serum sFRP5,HSP60 and SLC16A11 was 0.924,indicating that the combined diagnostic value of three indicators was superior to that of each individual indicator(all P＜0.05).Conclusion GDM patients exhibit decreased serum sFRP5 level and increased HSP60 and SLC16A11 levels;three indicators are factors influencing the occurrence of GDM in pregnant pa-tients,and are associated with insulin resistance;the combination of three indicators exhibits high diagnostic efficacy for GDM.关键词
分泌性卷曲相关蛋白-5/热休克蛋白60/溶质载体家族16成员11/妊娠期糖尿病/胰岛素抵抗Key words
secreted frizzled-related protein 5/heat shock protein 60/solute carrier family 16 member 11/gestational diabetes mellitus/insulin resistance分类
医药卫生引用本文复制引用
魏曼,苑文贺,刘红云,马迪蒙,闫康禄,韩宁..妊娠期糖尿病患者血清分泌性卷曲相关蛋白-5、热休克蛋白60、溶质载体家族16成员11的表达及其与胰岛素抵抗的关系[J].实用临床医药杂志,2024,28(20):60-65,6.基金项目
河南省科技发展计划项目(222102310129) （222102310129）
