实用临床医药杂志2024，Vol.28Issue(20)：86-91,6.DOI:10.7619/jcmp.20242347
妊娠糖尿病孕妇血清谷胱甘肽过氧化物酶3、水通道蛋白9表达水平及意义
Expression levels and significance of serum glutathione peroxidase 3 and aquaporin 9 in pregnant women with gestational diabetes mellitus
摘要
Abstract
Objective To investigate the changes in the expression levels of serum glutathione peroxidase 3(GPX3)and aquaporin 9(AQP9)in pregnant women with gestational diabetes mellitus(GDM)and their relationships with pregnancy outcomes.Methods A total of 200 pregnant women with GDM(GDM group)and 200 healthy pregnant women(control group)were enrolled as study subjects.The GDM group was further divided into adverse pregnancy outcome(APO)subgroup(n=22)and favorable pregnancy outcome subgroup(n=178)based on pregnancy outcomes.The expres-sion levels of serum GPX3 and AQP9 were detected by enzyme-linked immunosorbent assay.Multivari-ate Logistic regression analysis was used to screen for influencing factors of APO in GDM pregnant women.Receiver operating characteristic(ROC)curves were plotted to analyze the predictive perform-ance of serum GPX3 and AQP9 expression levels for APO in GDM pregnant women.Results Com-pared with the control group,the serum GPX3 expression level was decreased,and the serum AQP9 ex-pression level was increased in the GDM group(P＜0.05).The incidence of APO among the 200 GDM pregnant women was 11.00％(22/200).Compared with the favorable pregnancy outcome subgroup,the APO group had higher levels of homeostasis model assessment-insulin resistance index(HOMA-IR),fasting blood glucose,glycated hemoglobin(HbA1c),and AQP9,and lower levels of GPX3(P＜0.05).Multivariate Logistic regression analysis revealed that elevated HOMA-IR,HbA1c,and AQP9 were independent risk factors for APO in GDM pregnant women(P＜0.05),while elevated GPX3 was an independent protective factor(P＜0.05).The ROC curve showed that the areas under the curve(AUCs)for predicting APO in GDM pregnant women were 0.784(95％CI,0.673 to 0.881)for serum GPX3 alone,0.788(95％CI,0.687 to 0.894)for serum AQP9 alone,and 0.906(95％CI,0.805 to 0.972)for their combination,with the AUC for the combined prediction being greater than that for individual prediction(P＜0.05).Conclusion The serum GPX3 expression level is de-creased,and the serum AQP9 expression level is increased in GDM pregnant women.Both serum GPX3 and AQP9 are independent influencing factors for APO,and their combined prediction has a higher value for APO in GDM pregnant women.关键词
妊娠糖尿病/谷胱甘肽过氧化物酶3/水通道蛋白9/妊娠结局/酶联免疫吸附法/多因素回归分析Key words
gestational diabetes mellitus/glutathione peroxidase 3/aquaporin 9/pregnancy outcome/enzyme-linked immunosorbent assay/multivariate regression analysis分类
医药卫生引用本文复制引用
朱毛根,于康军,牛三强..妊娠糖尿病孕妇血清谷胱甘肽过氧化物酶3、水通道蛋白9表达水平及意义[J].实用临床医药杂志,2024,28(20):86-91,6.基金项目
安徽省重点研究与开发计划项目(2022e07020038) （2022e07020038）
安徽省亳州市卫健委科研项目(bzwj2022b2009) （bzwj2022b2009）
