军事医学2024，Vol.48Issue(10)：737-743,7.DOI:10.7644/j.issn.1674-9960.2024.10.003
人感染札如病毒的遗传多样性与重组事件分析
Genetic diversity and recombination events of human infections with Sapovirus
摘要
Abstract
Objective To investigate the genetic characteristics and recombination of human-infected sapoviruses(SaVs)worldwide using bioinformatics.Methods The complete genome sequences of SaVs were downloaded from the National Center for Biotechnology Information(NCBI)while high-quality complete genomes were retained for analysis.Molecular phylogenetic trees of SaVs were constructed to analyze their genetic characteristics,followed by recombination analysis of human-infected SaV strains genetype Ⅰ,Ⅱ,Ⅳ,and V(G Ⅰ,G Ⅱ,GⅣ,and GⅤ)with recombination analysis software.Results SaVs exhibited substantial genetic diversity worldwide and infected a wide range of hosts.Human-associated SaVs included G Ⅰ,G Ⅱ,GⅣ,and GⅤ,with GⅤ shared between human and swine hosts.Genetype recombination analysis of SaVs revealed a high frequency of recombination in SaV G Ⅱ strains that involved diverse hosts in the field of SaV G V strains.Recombination breakpoints of the virus were concentrated in the major viral proteins 1(VP1)and minor viral proteins 2(VP2).Conclusion Based on systematic analysis of the genetic characteristics of human-infected SaVs,the genotype distribution and prevalence of SaVs are investigated,the recombination patterns of SaV revealed,and its genetic dynamics highlighted.These findings can offer insights into epidemiological trends of viruses and help devise effective prevention and control strategies.关键词
札如病毒/系统发育树/遗传重组/遗传多样性/分子进化Key words
Sapovirus/phylogenetic tree/genetic recombination/genetic diversity/molecular evolution分类
医药卫生引用本文复制引用
刘婉秋,胡明达,胡晓丰,任洪广,王辛,何雅青..人感染札如病毒的遗传多样性与重组事件分析[J].军事医学,2024,48(10):737-743,7.基金项目
国家自然科学基金项目(32070025,62206309) （32070025,62206309）
病原微生物生物安全国家重点实验室研究项目(SKLPBS2214,SKLPBS2234) （SKLPBS2214,SKLPBS2234）
