日用化学工业（中英文）2024，Vol.54Issue(11)：1289-1297,9.DOI:10.3969/j.issn.2097-2806.2024.11.001
二氧化碳在水中的相转化及其优异的抗炎生理活性
Hydration transformation behaviors of CO2 and excellent anti-inflammatory activity on RAW 264.7 cell
摘要
Abstract
Skin care products with carbonic acid(H2CO3)have gained extensive attention worldwide.However,the conversion of CO2 to H2CO3 is not stable,and the mechanism of the effect of H2CO3 on skin care has not been clearly proved.The hydration-dissolution behaviors of CO2 were investigated under different temperature,pH,and pressure conditions.Moreover,based on the phenomenon of CO2 hydration transformation,the inflammatory effect of CO2 hydrate on macrophages(RAW 264.7)was investigated.The result shows that the increase in temperature weakened the hydration of CO2,and the increase in pH and pressure both promoted the water-phase transformation of CO2.When pH<6,CO2 reacts with water to generate H2CO3.When pH was between 6-7,the prompt solution was a mixture of H2CO3 and HCO3-.When the pH was between 7-9,they mainly generated HCO3-.And when pH>9,CO2 solubility mainly converts to CO32-.Besides,CO2 can inhibit the secretion of inflammatory factors by RAW 264.7 cells by inhibiting the phosphorylation of the p38 protein.CO2 hydrate inhibited the expression of pro-inflammatory factors IL-6,TNF-α,and up-regulated the expression of anti-inflammatory factor IL-10.Furthermore,the anti-inflammatory molecular mechanism of CO2 hydration inhibited the MAPK signaling pathway by inhibiting the phosphorylation of p38.The hydration-dissolution behavior of CO2 was investigated.This work revealed the anti-inflammatory bioeffect of CO2 hydrate,providing a theoretical basis and application support for CO2 skin care products.关键词
二氧化碳/水合作用/抗炎作用/皮肤护理Key words
CO2/hydration transformation/anti-inflammatory effect/skin care分类
化学化工引用本文复制引用
张婉萍,顾宜婷,李旭艳,孙志勇,魏春红,张冬梅..二氧化碳在水中的相转化及其优异的抗炎生理活性[J].日用化学工业（中英文）,2024,54(11):1289-1297,9.基金项目
国家自然科学基金资助项目(22302127) （22302127）
上海应用技术大学香料香精化妆品省部共建协同创新中心开放课题(XTCXC-202101) （XTCXC-202101）
上海应用技术大学协同创新基金项目(XTCX2022-30) （XTCX2022-30）
