日用化学工业（中英文）2024，Vol.54Issue(11)：1313-1319,7.DOI:10.3969/j.issn.2097-2806.2024.11.004
重组人钙网蛋白促雄激素性脱发小鼠毛发再生的作用研究
Recombinant human calreticulin promotes hair regeneration in androgenetic alopecia mice
摘要
Abstract
Androgenetic alopecia(AGA)is the most common type of hair loss and is usually caused by multiple factors.AGA is characterized by progressive miniaturization of hair follicles,shortened anagen phase,prolonged telogen phase,and the decrease of hair density.We studied the role of recombinant human calreticulin(rh-CRT)in promoting hair regeneration in androgenetic alopecia(AGA)mice.Hair regeneration was assessed by observing the overall and local appearance of the hair at different time points,the melanin index of the skin was observed by color tester,the change of hair diameter was detected by dermatoscopy,the change of the hair cuticle was studied by scanning electron microscopy,and the thickness of the skin and the dermal white adipose,and the number of hair follicles were further observed by HE staining.The results reveal that rh-CRT promotes hair regeneration,increases melanin index,significantly improves the diameters of coarse and fine hairs in AGA mice,and repairs the damaged hair cuticle induced by testosterone(TES).In addition,it is demonstrated that rh-CRT significantly promotes the number of hair follicles and the thickness of the skin and dermal white adipose in AGA mice.The results suggest that rh-CRT promotes the regeneration of hair in AGA mice,which has important application value in hair regeneration products.关键词
重组人钙网蛋白/雄激素性脱发/毛发再生Key words
recombinant human calreticulin/androgenetic alopecia/hair regeneration分类
化学化工引用本文复制引用
贺改英,吴首标,刘树涛,魏东东,崔俊生,王毅..重组人钙网蛋白促雄激素性脱发小鼠毛发再生的作用研究[J].日用化学工业（中英文）,2024,54(11):1313-1319,7.基金项目
国家自然科学基金青年基金(82204902) （82204902）
中央级公益性科研院所基本科研业务费(JBGS2023003) （JBGS2023003）
