日用化学工业（中英文）2024，Vol.54Issue(11)：1382-1390,9.DOI:10.3969/j.issn.2097-2806.2024.11.013
皮肤微生态调节型产品的评价方法概述
Efficacy assessment for skin microecology/microbiome-modulating cosmetics
郑玉梅 1胡熔 2吴文海 1宋丽雅 3王闻2
作者信息
- 1. 斯坦德科创医药科技(青岛)有限公司,山东 青岛 266000
- 2. 斯坦德科创医药科技(青岛)有限公司,山东 青岛 266000||斯坦德检测(广州)有限公司,广东 广州 510700
- 3. 北京工商大学 化学与材料工程学院,北京 100000
- 折叠
摘要
Abstract
The in vitro and in vivo evaluation methods of microecological skin care products were summarized.Cosmetics can regulate skin microecological balance by directly changing the number,growth metabolism,community structure,and population effect of skin microorganisms,or by regulating skin immune response and improving skin physiological function.The number,growth and metabolism level,population effect of skin microorganisms and skin immune response status are often evaluated by in vitro method.Skin microbial diversity,community structure,and skin physiological state are often tested by human methods,combined with high-throughput sequencing technologies such as 16S rRNA amplicon sequencing,ITS amplicon sequencing,and shotgun metagenomic sequencing.Different evaluation methods have different dimensions and advantages.The in vitro method is more targeted and the test conditions are easy to control,but the model is too simple and lack of activity.In contrast,clinical trials are more holistic and in line with real use scenarios,but it is difficult to qualitative analyze the complex causal relationship among individuals,product use and microbiome changes.In the process of efficacy evaluation,the combination of in vitro and in vivo can complement the limitations of different evaluation methods to a certain extent,and can provide a more complete evidence chain for the efficacy evaluation of products.关键词
皮肤微生态/评价方法/体外模型/动物模型/扩增子测序/宏基因组Key words
skin microbiome/efficacy assessment/in vitro/animal model/amplicon sequencing/metagenome分类
化学化工引用本文复制引用
郑玉梅,胡熔,吴文海,宋丽雅,王闻..皮肤微生态调节型产品的评价方法概述[J].日用化学工业（中英文）,2024,54(11):1382-1390,9.
