生物医学工程研究2024，Vol.43Issue(5)：409-417,9.DOI:10.19529/j.cnki.1672-6278.2024.05.09
β-烟酰胺单核苷酸的生物合成与纯化方法进展
Advances in the biosynthesis and purification of β-nicotinamide mononucleotide
摘要
Abstract
β-nicotinamide mononucleotide(NMN)is one of the key precursor substances for the synthesis of nicotinamide adenine dinucleotide(NAD+)in mammals.MNN can inhibit neural and vascular aging,improve the chronic diseases,and has broad applica-tion prospects in health food and medicine.Microbial synthesis of NMN is an economical and sustainable source,mainly obtained through rational methods such as metabolic engineering and synthetic biology.However,due to the long metabolic pathways,complex regulatory mechanisms,and unclear nature of NMN in microbial cells,production strains still face issues.This review summarizes the relevant progress in NMN biosynthesis and purification process applications,and briefly looks forward to future development trends,which can provide reference and guidance for subsequent related research and application.关键词
β-烟酰胺单核苷酸/烟酰胺腺嘌呤二核苷酸/生物发酵/代谢工程/合成生物学Key words
β-nicotinamide mononucleotide/Nicotinamide adenine dinucleotide/Fermentative production/Metabolic engineer-ing/Synthetic biology分类
医药卫生引用本文复制引用
李翔宇,侯宏卫,李景虹,田大勇,林森,姜兴益,柴颖,罗彦波,郭春生,郑超,庞永强..β-烟酰胺单核苷酸的生物合成与纯化方法进展[J].生物医学工程研究,2024,43(5):409-417,9.基金项目
中国烟草总公司重点研发项目(110202202027) （110202202027）
中国烟草总公司郑州烟草研究院科研开发项目(2023410103600010). （2023410103600010）
