肝细胞癌组织中细胞周期蛋白25C及其mRNA表达观察OACSTPCD

Objective To observe the expression changes of cell division cycle 25C protein and mRNA in hepatocel-lular carcinoma tissues.Methods Forty patients with hepatocellular carcinoma confirmed by pathological examination underwent surgery,and hepatocellular carcinoma tissues and their adjacent tissues were collected during surgery.The ex-pression of CDC25C protein and mRNA in hepatocellular carcinoma and adjacent tissues were detected by in situ hybridiza-tion and immunohistochemistry,respectively.Results The relative expression levels of CDC25C protein in hepatocellu-lar carcinoma tissues and adjacent tissues were 0.392±0.075 and 0.099±0.043,respectively,with a significant differ-ence between them(P<0.05).The relative expression levels of CDC25C mRNA in hepatocellular carcinoma tissues and adjacent tissues were 0.122±0.014 and 0.062±0.017,respectively,with a significant difference between them(P<0.05).Compared with patients with grade≤2,patients with grade>2 had higher expression levels of CDC25C protein and mRNA in hepatocellular carcinoma tissues(both P<0.05).Compared with patients without liver cirrhosis,patients with liver cirrhosis had higher expression levels of CDC25C protein and mRNA in hepatocellular carcinoma tissues(both P<0.05).The expression of CDC25C protein in hepatocellular carcinoma tissues was higher in females than in males(P<0.05).Conclusion CDC25C protein and mRNA are highly expressed in hepatocellular carcinoma tissues,and CDC25C may promote the development and progression of hepatocellular carcinoma.