山东医药2024，Vol.64Issue(30)：1-4,4.DOI:10.3969/j.issn.1002-266X.2024.30.001
肝细胞癌组织中细胞周期蛋白25C及其mRNA表达观察
Expression changes of cell division cycle 25C protein and mRNA in hepatocellular carcinoma tissues
摘要
Abstract
Objective To observe the expression changes of cell division cycle 25C protein and mRNA in hepatocel-lular carcinoma tissues.Methods Forty patients with hepatocellular carcinoma confirmed by pathological examination underwent surgery,and hepatocellular carcinoma tissues and their adjacent tissues were collected during surgery.The ex-pression of CDC25C protein and mRNA in hepatocellular carcinoma and adjacent tissues were detected by in situ hybridiza-tion and immunohistochemistry,respectively.Results The relative expression levels of CDC25C protein in hepatocellu-lar carcinoma tissues and adjacent tissues were 0.392±0.075 and 0.099±0.043,respectively,with a significant differ-ence between them(P<0.05).The relative expression levels of CDC25C mRNA in hepatocellular carcinoma tissues and adjacent tissues were 0.122±0.014 and 0.062±0.017,respectively,with a significant difference between them(P<0.05).Compared with patients with grade≤2,patients with grade>2 had higher expression levels of CDC25C protein and mRNA in hepatocellular carcinoma tissues(both P<0.05).Compared with patients without liver cirrhosis,patients with liver cirrhosis had higher expression levels of CDC25C protein and mRNA in hepatocellular carcinoma tissues(both P<0.05).The expression of CDC25C protein in hepatocellular carcinoma tissues was higher in females than in males(P<0.05).Conclusion CDC25C protein and mRNA are highly expressed in hepatocellular carcinoma tissues,and CDC25C may promote the development and progression of hepatocellular carcinoma.关键词
细胞分裂周期蛋白25C/肝肿瘤/原发性肝癌/肝细胞癌Key words
cell division cycle 25C/liver neoplasms/primary liver carcinoma/hepatocellular carcinoma分类
医药卫生引用本文复制引用
刘海龙,张琪惠,栗彦飞,张瑶尧,晁耐霞,莫发荣..肝细胞癌组织中细胞周期蛋白25C及其mRNA表达观察[J].山东医药,2024,64(30):1-4,4.基金项目
广西自然科学基金资助项目(2023GXNSFAA026070). （2023GXNSFAA026070）
