1990～2019年中国人群非霍奇金淋巴瘤的发病、病死及疾病负担变化趋势分析OACSTPCD
Changing trends in morbidity,mortality,and disease burden of non-Hodgkin lymphoma in Chinese population from 1990 to 2019
目的 分析 1990～2019 年中国人群非霍奇金淋巴瘤(Non-Hodgkin Lymphoma,NHL)的发病、病死及疾病负担变化趋势,旨在为中国NHL的防控提供参考.方法 从2019年全球疾病负担研究数据库中筛选1990～2019 年中国人群的NHL发病数、发病率、死亡数、死亡率、伤残调整寿命年(disability adjusted life years,DALYs)等资料.采用Joinpoint Regression Program 4.9.0.0软件进行Joinpoint回归分析,测算1990～2019 年中国NHL的标化发病率(ASIR)、年龄标化死亡率(Age-Standardized Mortality Rate,ASMR)及标化伤残调整生命年(Disability ad-justed life years,DALYs),分析1990～2019 年中国NHL发病、死亡及疾病负担的变化趋势,构建年龄-时期-队列模型(APC)分析不同年龄及时间中国人群NHL的发病风险、死亡风险及疾病负担.结果 1990～2019年中国人群NHL总体粗发病率、总体粗死亡率及总体粗DALYs率均呈增长趋势[平均年度变化百分比(AAPC)=4.7、2.8、1.8,P均<0.05].1990～2019年中国人群NHL标化ASIR、标化ASMR及标化 DALYs均呈增长趋势(AAPC=3.1、0.8、0.5,P均<0.05).中国人群NHL的疾病负担随年龄的增加而增加;随着年龄和时期的推移,中国男性、女性人群NHL的发病风险及死亡风险均增加,晚出生的中国人群NHL的发病风险及死亡风险低,男性和女性人群NHL疾病负担均呈先上升后下降趋势;随着时间变化,中国男性、女性和总体人群NHL的发病风险均呈上升趋势.结论 1990～2019 年中国人群NHL的发病率及死亡率呈上升趋势、疾病负担逐渐增加.男性及老年人群更易发生NHL、疾病负担更高.
Objective To analyze the changing trends of morbidity,mortality,and disease burden of non-Hodgkin lymphoma(NHL)in Chinese population from 1990 to 2019 in order to provide a reference for NHL prevention and con-trol.Methods Data on the number of cases,incidence rate,the number of deaths,mortality rate,and disability-adjust-ed life years(DALYs)for NHL in the Chinese population from 1990 to 2019 were extracted from the 2019 Global Burden of Disease Study database.Joinpoint regression analysis was conducted using the Joinpoint Regression Program 4.9.0.0 to calculate the age-standardized incidence rate(ASIR),age-standardized mortality rate(ASMR),and disability-adjusted life years(DALYs)for NHL in China from 1990 to 2019 and to analyze the changing trends of morbidity,mortality,and disease burden of NHL.Age-Period-Cohort(APC)modeling was used to analyze the onset risk,mortality risk,and dis-ease burden in Chinese population of different age groups and time periods.Results From 1990 to 2019,the overall crude incidence rate,overall crude mortality rate,and overall crude DALYs rate of NHL among the Chinese population showed an increasing trend(AAPC=4.7,2.8,and 1.8,respectively;all P<0.05).During the same period,the ASIR,ASMR,and age-standardized DALYs of the NHL also demonstrated an upward trend(AAPC=3.1,0.8,and 0.5,re-spectively;all P<0.05).With increasing age,the disease burden of NHL in the Chinese population rose;as age and peri-od increased,the incidence and mortality risks of NHL in both Chinese men and women increased.However,those born in later years exhibited lower incidence and mortality risks for NHL.The disease burden of NHL among males and females first rose and then declined.Over time,the incidence risk of NHL in Chinese males,females,and the overall population showed an upward trend.Conclusions From 1990 to 2019,the incidence and mortality rates of NHL in the Chinese population exhibit an upward trend,with an increasing disease burden.Males and the elderly population are more suscepti-ble to NHL,with a higher disease burden.
宁祖乐;李嘉怡;曾婉琪;刘沁娴;杜进林
广东医科大学公共卫生学院,广东 东莞 523000
临床医学
疾病负担标化发病率标化死亡率伤残调整生命年非霍奇金淋巴瘤
burden of diseaseage-standardized incidence rateage-standardized mortality ratedisability-adjust-ed life yearsnon-Hodgkin lymphoma
《山东医药》 2024 (030)
19-23 / 5
广东省教育科学"十三五"规划2019年度高校哲学社会科学专项资助(2019GXJK226);广东省研究生教育创新计划研究项目(2020JGXM056).
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