山东医药2024，Vol.64Issue(30)：19-23,5.DOI:10.3969/j.issn.1002-266X.2024.30.005
1990～2019年中国人群非霍奇金淋巴瘤的发病、病死及疾病负担变化趋势分析
Changing trends in morbidity,mortality,and disease burden of non-Hodgkin lymphoma in Chinese population from 1990 to 2019
摘要
Abstract
Objective To analyze the changing trends of morbidity,mortality,and disease burden of non-Hodgkin lymphoma(NHL)in Chinese population from 1990 to 2019 in order to provide a reference for NHL prevention and con-trol.Methods Data on the number of cases,incidence rate,the number of deaths,mortality rate,and disability-adjust-ed life years(DALYs)for NHL in the Chinese population from 1990 to 2019 were extracted from the 2019 Global Burden of Disease Study database.Joinpoint regression analysis was conducted using the Joinpoint Regression Program 4.9.0.0 to calculate the age-standardized incidence rate(ASIR),age-standardized mortality rate(ASMR),and disability-adjusted life years(DALYs)for NHL in China from 1990 to 2019 and to analyze the changing trends of morbidity,mortality,and disease burden of NHL.Age-Period-Cohort(APC)modeling was used to analyze the onset risk,mortality risk,and dis-ease burden in Chinese population of different age groups and time periods.Results From 1990 to 2019,the overall crude incidence rate,overall crude mortality rate,and overall crude DALYs rate of NHL among the Chinese population showed an increasing trend(AAPC=4.7,2.8,and 1.8,respectively;all P<0.05).During the same period,the ASIR,ASMR,and age-standardized DALYs of the NHL also demonstrated an upward trend(AAPC=3.1,0.8,and 0.5,re-spectively;all P<0.05).With increasing age,the disease burden of NHL in the Chinese population rose;as age and peri-od increased,the incidence and mortality risks of NHL in both Chinese men and women increased.However,those born in later years exhibited lower incidence and mortality risks for NHL.The disease burden of NHL among males and females first rose and then declined.Over time,the incidence risk of NHL in Chinese males,females,and the overall population showed an upward trend.Conclusions From 1990 to 2019,the incidence and mortality rates of NHL in the Chinese population exhibit an upward trend,with an increasing disease burden.Males and the elderly population are more suscepti-ble to NHL,with a higher disease burden.关键词
疾病负担/标化发病率/标化死亡率/伤残调整生命年/非霍奇金淋巴瘤Key words
burden of disease/age-standardized incidence rate/age-standardized mortality rate/disability-adjust-ed life years/non-Hodgkin lymphoma分类
医药卫生引用本文复制引用
宁祖乐,李嘉怡,曾婉琪,刘沁娴,杜进林..1990～2019年中国人群非霍奇金淋巴瘤的发病、病死及疾病负担变化趋势分析[J].山东医药,2024,64(30):19-23,5.基金项目
广东省教育科学"十三五"规划2019年度高校哲学社会科学专项资助(2019GXJK226) （2019GXJK226）
广东省研究生教育创新计划研究项目(2020JGXM056). （2020JGXM056）
