山东医药2024，Vol.64Issue(30)：24-28,5.DOI:10.3969/j.issn.1002-266X.2024.30.006
系统性红斑狼疮患者凝血—纤溶功能变化与疾病活动的关系
Relationships between changes in coagulation and fibrinolysis function and disease activity in patients with systemic lupus erythematosus
摘要
Abstract
Objective To observe the changes of coagulation and fibrinolysis function in patients with systemic lu-pus erythematosus(SLE),and to explore their relationships with the disease activity indicators and different system dam-age.Methods Peripheral venous blood was collected from 109 SLE patients and 100 healthy subjects in our hospital.Coagulation-fibrinolytic indexes[activated partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen(FIB),fibrin degradation products(FDP),D-2 polymers(DD)]and SLE disease activity indexes[erythrocyte sedimentation rate(ESR),complement(C)3,C4,anti-double-stranded DNA(anti-dsDNA)antibody,C-reactive protein(CRP),immunoglobulin G(IgG),IgM,and IgA]were detected.The plasma APTT,PT,TT,FIB,FDP,and DD in SLE patients with different disease activity and different system damage were compared.Pearson or Spear-man rank correlation analysis was used to analyze the correlations between APTT,PT,TT,FIB,FDP,DD levels and dis-ease activity indicators.Univariate and multivariate Logistic regression analysis were used to analyze the influencing fac-tors of disease activity in SLE patients.Results Compared with healthy subjects,the levels of PT,FIB,FDP and DD in SLE patients increased(all P<0.05);compared with non-active SLE patients(SLEDAI score<5),SLE patients with ac-tive SLE(SLEDAI score≥5)had higher levels of FIB,FDP and DD(all P<0.05).The levels of FIB,FDP and DD in SLE patients with renal lesions were higher than those without renal lesions(all P<0.05).The plasma FIB level of SLE pa-tients with interstitial lung disease(ILD)was higher than that of patients without ILD(all P<0.05).Compared with pa-tients without serositis,SLE patients with serositis had higher plasma PT,APTT,FDP and DD levels;compared with those without blood system involvement,SLE patients with blood system involvement had longer PT and APTT(both P<0.05).The plasma PT level was positively correlated with ESR and was negatively correlated with C3 in SLE patients(all P<0.05).APTT was positively correlated with ESR,IgG and anti-dsDNA antibody levels,and was negatively correlated with C3 and C4 levels(all P<0.05).FIB was positively correlated with ESR,IgG,C4,IgA and SLEDAI score(all P<0.05).Plasma DD was positively correlated with ESR,CRP,IgG,anti-dsDNA antibody levels and SLEDAI score in SLE patients(all P<0.05).FDP was positively correlated with ESR,CRP,IgG,anti-dsDNA antibody levels and SLEDAI score(all P<0.05).Univariate Logistic regression analysis showed that the increased FIB,ESR,IgA,IgG and anti-dsD-NA antibody and the decreased C3 were the risk factors for SLE disease activity(all P<0.05).Multiple Logistic regression analysis showed that the increased FIB,ESR,IgG and anti-dsDNA antibody levels were the independent risk factors for SLE disease activity(all P<0.05).Conclusions The plasma levels of PT,FIB,DD and FDP increase in SLE patients,and different coagulation-fibrinolysis indexes increase in disease activity groups and patients with different systems im-paired SLE.Increased levels of plasma FIB,ESR,IgG and anti-dsDNA antibody indicate SLE disease activity,and abnor-mal coagulation-fibrinolysis index may indicate the impairment of different systems of SLE.关键词
凝血系统/纤溶系统/疾病活动/系统损害/红斑狼疮/系统性Key words
coagulation/fibrinolysis/disease activity/system damage/lupus erythematosus/systematicness分类
医药卫生引用本文复制引用
俞烜华,刘昌泉,张莹,张伟桢,吕雪冰,李扬宇,吴月萍,黄惠娟..系统性红斑狼疮患者凝血—纤溶功能变化与疾病活动的关系[J].山东医药,2024,64(30):24-28,5.基金项目
福建省教育厅资助项目(JT180226) （JT180226）
福建省自然科学基金资助项目(2022J01851) （2022J01851）
福建省卫健委中青年骨干人才项目(2023GGA071). （2023GGA071）
