饲料研究2024，Vol.47Issue(20)：51-55,5.DOI:10.13557/j.cnki.issn1002-2813.2024.20.010
发酵麸皮多糖对胆固醇诱导的高脂斑马鱼脂肪代谢和抗氧化相关指标的影响
Effects of fermented wheat bran polysaccharides on lipid metabolism and antioxidant-related indexes of cholesterol-induced high fat zebrafish
摘要
Abstract
The study was to investigate the effects of fermented wheat bran polysaccharides(FWBP)on the fat metabolism and antioxidant-related indicators in cholesterol-induced high-fat zebrafish.This study mainly used 5 dpf wild-type AB zebrafish as experimental animals.Firstly,a high-fat zebrafish model was constructed.It was clear that 5％high cholesterol diet could cause a significant increase in fat accumulation in zebrafish.On this basis,FWBP(0,0.25,0.50,0.75,1.00％o)was added to study whether it could improve cholesterol-induced fat metabolism and antioxidant dysfunction.Each group was subdivided into five replicates,with 30 zebrafishes per replicate.The experiment lasted for 10 days.The results showed that compared to the control group,the TC,TG,and LDL contentrations,as well as the activities of AST,ALT,and GGT of zebrafish in f 0.50‰ FWBP group were all significantly reduced(P＜0.05),the HDL content of fish in 1.00‰ FWBP group was significantly reduced(P＜0.05).Compared to the control group,the activities of SOD,CAT,and GSH-Px of fish in 0.25‰,0.50‰,and 0.75‰ FWBP groups were all significantly increased(P＜0.05),and the MDA content in all experimental groups was significantly decreased(P＜0.05).The study indicates that FWBP can effectively reduce the total fat and lipoprotein content in zebrafish after consuming high-fat feed,decrease the activity of enzymes related to fat metabolism and the content of TBIL,enhance the activity of antioxidant enzymes,reduce MDA content,alleviate oxidative stress caused by high fat,with the best effect observed at the addition of 0.50‰.关键词
发酵麸皮多糖/高脂模型/斑马鱼/脂肪代谢/抗氧化Key words
fermented wheat bran polysaccharide/high fat model/zebrafish/fat metabolism/antioxidation分类
农业科技引用本文复制引用
刘从富,王瑞芳,齐景伟,安晓萍,王园,杨艳平,宋敏..发酵麸皮多糖对胆固醇诱导的高脂斑马鱼脂肪代谢和抗氧化相关指标的影响[J].饲料研究,2024,47(20):51-55,5.基金项目
内蒙古自治区高等学校科学研究项目(项目编号:NJZY21499) （项目编号:NJZY21499）
