饲料研究2024，Vol.47Issue(20)：86-90,5.DOI:10.13557/j.cnki.issn1002-2813.2024.20.016
4取代三联吡啶钴和镍的抗菌活性研究
Study on antibacterial activity of 4-substituted tripyridyl cobalt and nickel
摘要
Abstract
The experiment aimed to study the antibacterial activity and mechanism of 4-substituted terpyridine cobalt and nickel complexes.The experiment used the two-fold dilution method to determine the minimum inhibitory concentration(MIC)of 10 different 4-substituted terpyridine cobalt and nickel metal complexes against six common pathogenic bacteria(Salmonella enterica,Staphylococcus aureus,Pseudomonas aeruginosa,Escherichia coli K99,Streptococcus agalactiae,and Vibrio parahaemolyticus),and analyzed their antibacterial activity.The results showed that the complexes had good inhibitory effects on Staphylococcus aureus,with generally low MIC values,among which the MIC of LB3 NiCl2 against Staphylococcus aureus was as low as 5 mg/L.The growth curve and death curve of Staphylococcus aureus showed that LB3 NiCl2 inhibited bacterial growth to varying degrees and had concentration dependence.The results of fluorescence microscopy observation showed that the permeability of bacterial cell membranes increased after treatment with metal complexes.The study indicates that 4-substituted terpyridine cobalt and nickel complexes have good antibacterial activity against Staphylococcus aureus.关键词
三联吡啶/镍配合物/抗菌活性/金黄色葡萄球菌Key words
terpyridine/nickel complexes/antibacterial activity/Staphylococcus aureus分类
农业科技引用本文复制引用
罗家其,马成,黄清萍,谢芝港,江明生,刘宏鸣,陈海兰..4取代三联吡啶钴和镍的抗菌活性研究[J].饲料研究,2024,47(20):86-90,5.基金项目
大学生创新创业训练项目(项目编号:202310593451) （项目编号:202310593451）
巴马人才科技专项(项目编号:202101267) （项目编号:202101267）
