饲料研究2024，Vol.47Issue(20)：165-171,7.DOI:10.13557/j.cnki.issn1002-2813.2024.20.031
沙门氏菌感染家禽的致病与免疫应答机制研究进展
Research progress on pathogenicity and immune response mechanism of Salmonella infected poultry
摘要
Abstract
Salmonella can cause infection in poultry and lead to intestinal lesions,and food-borne infections in humans through food transmission.Salmonella enters the intestines of poultry through oral ingestion,adheres to and invades intestinal epithelial cells,uses M cells and macrophages to achieve intracellular survival and reproduction,and causes intestinal lesions and systemic invasion.Virulence genes and plasmids are regulated during this process,including SPI-1 and SPI-2 encoded type[Ⅱ secretion systems and induced filamentous formation that help bacteria evade host defenses.Birds enhance their ability to clear Salmonella by regulating the synergistic effect of innate immune system and adaptive immune system.In this paper,the etiology,transmission route,pathogenesis and immune response mechanism of Salmonella were described,in order to provide reference for further study of Salmonella infection in poultry.关键词
沙门氏菌/家禽/致病/免疫应答/机制Key words
Salmonella/poultry/pathogenesis/immune response/mechanisms分类
农业科技引用本文复制引用
盛英霞,江海洋,顾华兵..沙门氏菌感染家禽的致病与免疫应答机制研究进展[J].饲料研究,2024,47(20):165-171,7.基金项目
山东省重点研发计划(项目编号:2022TZXD0016) （项目编号:2022TZXD0016）
山东省农业科学院农业科技创新工程(项目编号:CXGC2023A23) （项目编号:CXGC2023A23）
