山西医科大学学报2024，Vol.55Issue(10)：1358-1363,6.DOI:10.13753/j.issn.1007-6611.2024.10.014
射波刀在不可切除肝内胆管癌治疗中的应用
Application of CyberKnife in the treatment of unresectable intrahepatic cholangiocarcinoma
王梓萌 1潘艳霞 2李振华 2阎凯 3李铁华 1马宏宾1
作者信息
- 1. 海军军医大学第三附属医院放疗科,上海 200438
- 2. 海军军医大学第二附属医院门诊部
- 3. 海军军医大学第二附属医院胸外科
- 折叠
摘要
Abstract
Objective To evaluate the clinical efficacy of CyberKnife for inoperable intrahepatic cholangiocarcinoma(ICC).Methods CyberKnife was performed in Third Affiliated Hospital of Naval Medical University from January 2019 to December 2022.Long-term follow-up was performed in 38 patients with unresectable ICC in CyberKnife.MRI was performed every 2-3 months after radiotherapy to assess the effectiveness of treatment.Kaplan-Meier method was used to evaluate the overall survival(OS)and the pro-gression-free survival(PFS),and multi-factor Cox regression was used to analyze independent risk factors affecting overall survival.Results The median follow-up time was 10.5(3-62)months,the median PFS was 6(95%CI 2.605-9.395)months,and the median OS was 18(95%CI 6.474-29.526)months.Based on the modified solid tumor response evaluation criteria(mRECIST),the response rate(RR)and the disease control rate(DCR)of SBRT in unresectable ICC patients were 60.5%and 86.8%,respectively.The 1-year,2-year and 3-year overall survival rates were 50.9%,35.8%and 21.5%,respectively,and the 1-year,2-year and 3-year PFS were 32.4%,10.8%and 2.7%,respectively.Multivariate analysis based on Cox proportional hazards model showed that the patients with large tumor and high CA19-9 level had poorer overall survival(P<0.05).No adverse effects above grade 3 were observed in all patients.Conclusion CyberKnife is safe and effective for inoperable ICC patients.关键词
射波刀/立体定向放射治疗/不可切除肝内胆管癌/临床疗效/预后因素Key words
CyberKnife/stereotactic body radiation therapy/unresectable intrahepatic cholangiocarcinoma/clinical efficacy/prognostic factor分类
医药卫生引用本文复制引用
王梓萌,潘艳霞,李振华,阎凯,李铁华,马宏宾..射波刀在不可切除肝内胆管癌治疗中的应用[J].山西医科大学学报,2024,55(10):1358-1363,6.
