实用休克杂志（中英文）2024，Vol.8Issue(3)：148-151,155,5.
铁死亡相关蛋白GPX4在脓毒症心肌损伤中表达与血管内皮损伤的关系
Expression of iron-death related protein GPX4 with myocardial injury in sepsis and its relationship with vascular endothelial injury
摘要
Abstract
Objective To observe the expression of ferroptosis-related protein GPX4 in patients with myocardial injury caused by sepsis,analyze its correlation with vascular endothelial injury,and assess its diagnostic value for sepsis.Methods Clinical data of 146 sepsis patients admitted to our hospital from April 2021 to May 2024 were collected.According to left ventricular ejection fraction(LVEF),patients were divided into myocardial injury group(n=77)and non-injury group(n=69).LVEF was measured,and serum levels of glutathione peroxidase 4(GPX4),B-type natriuretic pep-tide(BNP),creatine kinase-MB(CK-MB),cardiac troponin Ⅰ(cTnⅠ),von Willebrand factor(vWF),endothelin-1(ET-1),and nitric oxide(NO)were tested.The correlation between GPX4 levels and vascular endothelial injury factors,and the diagnostic efficacy of GPX4 for myocardial injury in sepsis were analyzed.Results Compared to the non-injury group,the myocardial injury group had signifi-cantly higher levels of BNP,CK-MB,and cTnⅠ(P＜0.05)and significantly lower GPX4 levels(P＜0.05).Endothelial injury factors vWF and ET-1 were elevated,while NO levels were reduced(P＜0.05).Correlation analysis showed that GPX4 levels were positively correlated with NO expression(r=0.87,P＜0.001)and negatively correlated with vWF and ET-1 levels(r=-0.80,P＜0.001;r=-0.81,P＜0.001).ROC curve analysis indicated that GPX4 has a high predictive value for myo-cardial injury[area under the curve(AUC)=0.83,P＜0.001],with an optimal cutoff value of 0.559 8(sensitivity=92.21％,specificity=63.77％).Conclusions Ferroptosis-related protein GPX4 is lowly expressed in the serum of sepsis patients with myocardial injury,and its level is closely related to vascular endothelial function.GPX4 could serve as a potential marker for evaluating myocar-dial injury in sepsis patients.关键词
谷胱甘肽过氧化物酶4/脓毒症心肌损伤/血管内皮损伤Key words
Glutathione peroxidase4/sepsis induced myocardial injury/Vascular endothelial injury引用本文复制引用
李招兵,周琴怡,江振涛,黄云辉..铁死亡相关蛋白GPX4在脓毒症心肌损伤中表达与血管内皮损伤的关系[J].实用休克杂志（中英文）,2024,8(3):148-151,155,5.基金项目
1.湖南省卫生健康委科研计划项目(项目编号:202203014061) （项目编号:202203014061）
2.湖南省科技创新计划项目(项目编号:2021SK51905) （项目编号:2021SK51905）
