沈阳医学院学报2024，Vol.26Issue(6)：575-581,7.DOI:10.16753/j.cnki.1008-2344.2024.06.004
血清维生素A水平对糖尿病患者死亡风险的影响:一项前瞻性研究
Impact of serum vitamin A levels on all-cause mortality risk in diabetes patients:a prospective study
摘要
Abstract
Objective:To investigate the impact of serum vitamin A levels on all-cause mortality risk in diabetes patients.Methods:Diabetes patients aged 20 years and above who participated in the US National Health and Nutrition Examination Survey during 2003-2004 and 2005-2006 were enrolled as the study population,with death data up to 2019 as the endpoint.Cox proportional hazards regression models were employed to calculate the hazard ratios of all-cause mortality in diabetes patients with different serum vitamin A levels,both unadjusted and adjusted for confounders.Restricted cubic spline methods were used to analyze the dose-response relationship between serum vitamin A levels and all-cause mortality risk in diabetes patients.Results:A total of 484 diabetes patients were included,with a median follow-up period of 13.7 years,during which 211 deaths occurred.Cox proportional hazards analysis showed that compared to the lowest quartile of serum vitamin A,higher quartiles of serum vitamin A were not associated with all-cause mortality risk in diabetes patients without adjusting for confounders.However,after adjusting for confounders,higher quartiles of serum vitamin A significantly reduced the all-cause mortality risk.The dose-response analysis indicated a significantly increased risk of all-cause mortality in diabetes patients with lower serum vitamin A levels.As the vitamin A levels increased,the mortality risk gradually decreased.A significant reduction in all-cause mortality risk was observed when serum vitamin A levels were between 2.17 and 2.50 μmol/L.Beyond this range,there was a tendency for increased all-cause mortality risk with further increases in vitamin A levels.Conclusion:Lower serum vitamin A levels increase the all-cause mortality risk in diabetes patients,while moderate serum vitamin A levels help reduce the all-cause mortality risk in diabetes patients.关键词
维生素A/糖尿病/死亡风险Key words
vitamin A/diabetes/mortality risk分类
医药卫生引用本文复制引用
李卓,蒋保源,欧阳玉,相雅馨,杨桢,郭连莹..血清维生素A水平对糖尿病患者死亡风险的影响:一项前瞻性研究[J].沈阳医学院学报,2024,26(6):575-581,7.基金项目
沈阳医学院研究基金(No.20171018) （No.20171018）
