沈阳医学院学报2024，Vol.26Issue(6)：589-596,8.DOI:10.16753/j.cnki.1008-2344.2024.06.006
基于NRS评分的老年脓毒症患者预后列线图的建立与验证
Establishment and validation of a prognostic nomogram based on NRS score in elderly patients with sepsis
摘要
Abstract
Objective:To determine the prognostic factors in elderly patients with sepsis and to establish a prognostic model for predicting short-term mortality based on nutrition risk screening scores(NRS-2002).Methods:Demographic details,clinical information,data on biological marker of 426 elderly patients with sepsis were collected and NRS-2002 score were calculated within the first 24 hours of hospital admission.In a 7∶3 ratio,these patients were randomly divided into the training group and the validation group.The Lasso regression model was used to reduce data dimensions and select features.Cox regression analysis was conducted to analyze prognostic signature,based on which a nomogram was developed,and its predictive accuracy was evaluated.Results:Lasso regression analysis and multiple Cox regression analysis showed that albumin,urea nitrogen,lactic acid,and NRS-2002 score were independent risk factors that affected the 30-day prognosis of elderly patients with sepsis(P＜0.05).The areas under the receiver operating characteristic curves of the nomogram in the training and validation groups were 0.772(95%CI:0.734-0.812)and 0.730(95%CI:0.695-0.766),respectively.The calibration curves were fitted well in the two groups.Conclusion:The construction of prognostic nomogram based on NRS score can help clinicians timely assess the early risk of death in elderly patients with sepsis and accordingly take proactive measures.关键词
老年患者/脓毒症/生物标志物/营养风险筛查/预测模型Key words
elderly patients/sepsis/biomarkers/nutritional risk screening/prediction model分类
医药卫生引用本文复制引用
李芳,周卫凤,潘敏,王书..基于NRS评分的老年脓毒症患者预后列线图的建立与验证[J].沈阳医学院学报,2024,26(6):589-596,8.基金项目
安徽省教育厅自然科学研究重点项目(No.2022AH052334) （No.2022AH052334）
