武警医学2024，Vol.35Issue(11)：926-929,934,5.
龈沟液sST2、FGF21水平对牙种植体周围黏膜炎的预测价值
The levels and significance of sST2 and FGF21 in gingival crevicular fluid of periimplant mucositis patients
冯立娜 1张蕾1
作者信息
- 1. 100039 北京,解放军总医院第三医学中心口腔科
- 折叠
摘要
Abstract
Objective To investigate the changes and clinical significance of soluble human matrix metalloproteinase-2(sST2)and fibroblast growth factor 21(FGF21)levels in gingival crevicular fluid of patients with periimplant mucositis.Methods A total of 97 patients with periimplant mucositis from June 2022 to June 2024 in the Third Medical Center of Chinese PLA General Hospital were selected as the ob-servation group,Another 97 healthy natural tooth gingival volunteers were selected as the natural tooth control group,and 97 healthy peri im-plantitis gingival volunteers were selected as the implant control group.Enzyme linked immunosorbent assay(ELISA)was applied to detect the expression levels of sST2 and FGF21 in gingival crevicular fluid of two groups.Multivariate logistic regression was applied to analyze the factors affecting poor prognosis in patients.The receiver operating characteristic(ROC)curve was plotted to evaluate the predictive ability of sST2 and FGF21 levels for poor prognosis.Results Compared with the natural tooth control group and the implant control group,the expres-sion levels of sST2 and FGF21 in gingival crevicular fluid of patients in the observation group were increased(P<0.05).The expression lev-els of sST2 and FGF21 in gingival crevicular fluid of patients with poor prognosis were higher than those of patients with good prognosis(P<0.05).Multivariate logistic analysis showed that gingival bleeding index,probing depth,gingival crevicular fluid volume,sST2,and FGF21 were risk factors for poor prognosis in patients with periimplant mucositis(P<0.05).ROC curve results showed that the area under the curve(AUC)for predicting poor prognosis in patients with periimplant mucositis by combining sST2 and FGF21 in gingival crevicular fluid was 0.920,which was obviously larger than that predicted by sST2 alone(Z=2.046,P=0.041)and FGF21 alone(Z=2.407,P=0.016).Conclusion The levels of sST2 and FGF21 in gingival crevicular fluid of patients with periimplant mucositis are elevated,and the combina-tion of the two has a high predictive power for prognosis.关键词
牙种植体周围黏膜炎/龈沟液/可溶性人基质裂解素/成纤维细胞生长因子21Key words
Periimplant mucositis/gingival crevicular fluid/soluble suppression of tumorigenicity 2/fibroblast growth factor 21分类
医药卫生引用本文复制引用
冯立娜,张蕾..龈沟液sST2、FGF21水平对牙种植体周围黏膜炎的预测价值[J].武警医学,2024,35(11):926-929,934,5.
