龈沟液sST2、FGF21水平对牙种植体周围黏膜炎的预测价值OACSTPCD
The levels and significance of sST2 and FGF21 in gingival crevicular fluid of periimplant mucositis patients
目的 探讨牙种植体周围黏膜炎龈沟液可溶性人基质裂解素(sST2)、成纤维细胞生长因子 21(FGF21)水平变化的临床意义.方法 选取 2022-06 至 2024-06 就诊于解放军总医院第三医学中心牙种植体周围黏膜炎患者为观察组,共97 例,另选取同期 97 例天然牙牙龈健康志愿者为天然牙对照组,97 例种植体周围牙龈健康者为种植体对照组.采用酶联免疫吸附(ELISA)法对 3 组人员龈沟液中sST2、FGF21 表达水平检测;多因素logistic回归分析患者预后不良影响因素;绘制受试者工作特征(ROC)曲线评估sST2、FGF21 水平对患者预后不良预测能力.结果 与天然牙对照组和种植体对照组相比,观察组患者龈沟液sST2、FGF21 表达水平升高(P<0.05);预后不良患者龈沟液sST2、FGF21 表达水平高于预后良好患者(P<0.05);多因素logistic分析显示龈沟出血指数、探诊深度、龈沟液量、sST2、FGF21 是种植体周围黏膜炎患者预后不良的危险因素(P<0.05);ROC曲线结果表明,龈沟液sST2、FGF21 两者联合预测种植体周围黏膜炎患者预后不良的曲线下面积(AUC)为0.920,显著大于sST2(Z=2.046,P=0.041)和FGF21(Z=2.407,P=0.016)单独预测.结论 牙种植体周围黏膜炎患者龈沟液中sST2、FGF21 水平升高,二者联合对患者预后具有较高的预测效能.
Objective To investigate the changes and clinical significance of soluble human matrix metalloproteinase-2(sST2)and fibroblast growth factor 21(FGF21)levels in gingival crevicular fluid of patients with periimplant mucositis.Methods A total of 97 patients with periimplant mucositis from June 2022 to June 2024 in the Third Medical Center of Chinese PLA General Hospital were selected as the ob-servation group,Another 97 healthy natural tooth gingival volunteers were selected as the natural tooth control group,and 97 healthy peri im-plantitis gingival volunteers were selected as the implant control group.Enzyme linked immunosorbent assay(ELISA)was applied to detect the expression levels of sST2 and FGF21 in gingival crevicular fluid of two groups.Multivariate logistic regression was applied to analyze the factors affecting poor prognosis in patients.The receiver operating characteristic(ROC)curve was plotted to evaluate the predictive ability of sST2 and FGF21 levels for poor prognosis.Results Compared with the natural tooth control group and the implant control group,the expres-sion levels of sST2 and FGF21 in gingival crevicular fluid of patients in the observation group were increased(P<0.05).The expression lev-els of sST2 and FGF21 in gingival crevicular fluid of patients with poor prognosis were higher than those of patients with good prognosis(P<0.05).Multivariate logistic analysis showed that gingival bleeding index,probing depth,gingival crevicular fluid volume,sST2,and FGF21 were risk factors for poor prognosis in patients with periimplant mucositis(P<0.05).ROC curve results showed that the area under the curve(AUC)for predicting poor prognosis in patients with periimplant mucositis by combining sST2 and FGF21 in gingival crevicular fluid was 0.920,which was obviously larger than that predicted by sST2 alone(Z=2.046,P=0.041)and FGF21 alone(Z=2.407,P=0.016).Conclusion The levels of sST2 and FGF21 in gingival crevicular fluid of patients with periimplant mucositis are elevated,and the combina-tion of the two has a high predictive power for prognosis.
冯立娜;张蕾
100039 北京,解放军总医院第三医学中心口腔科100039 北京,解放军总医院第三医学中心口腔科
口腔医学
牙种植体周围黏膜炎龈沟液可溶性人基质裂解素成纤维细胞生长因子21
Periimplant mucositisgingival crevicular fluidsoluble suppression of tumorigenicity 2fibroblast growth factor 21
《武警医学》 2024 (11)
926-929,934,5
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