临床医学工程2024，Vol.31Issue(11)：1403-1404,2.DOI:10.3969/j.issn.1674-4659.2024.11.1403
紫杉醇联合顺铂同步放化疗在晚期食管癌患者中的应用效果分析
Analysis on the Application Effect of Paclitaxel Combined with Cisplatin Concurrent Chemoradiotherapy in Patients with Advanced Esophageal Cancer
宁琳琳 1潘雪峰 1王小利1
作者信息
- 1. 中国人民解放军联勤保障部队第989 医院肿瘤科,河南 洛阳 471100
- 折叠
摘要
Abstract
Objective To analyze the application effect of paclitaxel combined with cisplatin concurrent chemoradiotherapy in patients with advanced esophageal cancer.Methods 100 patients with advanced esophageal cancer were randomly divided into control group(50 cases,5-FU combined with cisplatin concurrent chemoradiotherapy)and observation group(50 cases,paclitaxel combined with cisplatin concurrent chemoradiotherapy).The clinical efficacy,serum tumor marker levels and adverse reactions were compared between the two groups.Results No statistical difference was found in the objective remission rate(70.00％vs.52.00％)between the two groups(P>0.05);The disease control rate of the observation group was 92.00％,higher than 74.00％of the control group(P<0.05).After 6 cycles of treatment,the serum CYFRA21-1 and SCC levels of the observation group were lower than those of the control group(P<0.05);No statistical difference was found in the incidence of adverse reactions(12.00％vs.14.00％)between the two groups during treatment(P>0.05).Conclusions Paclitaxel combined with cisplatin concurrent chemoradiotherapy can improve the disease control rate of advanced esophageal cancer,down-regulate the serum tumor marker levels,and ensure the medication safety.关键词
晚期食管癌/紫杉醇/顺铂/同步放化疗/肿瘤标志物Key words
Advanced esophageal cancer/Paclitaxel/Cisplatin/Concurrent chemoradiotherapy/Tumor marker分类
医药卫生引用本文复制引用
宁琳琳,潘雪峰,王小利..紫杉醇联合顺铂同步放化疗在晚期食管癌患者中的应用效果分析[J].临床医学工程,2024,31(11):1403-1404,2.
