针刺研究2024，Vol.49Issue(11)：1198-1204,7.DOI:10.13702/j.1000-0607.20230636
贺氏强通法对急性缺血性脑卒中患者神经血管单元的修复作用
Effect of He's qiangtong method of acupuncture on serological levels in patients with acute ischaemic stroke
摘要
Abstract
Objective To investigate the repair effects of He's qiangtong method of acupuncture(involved bloodletting technique with strong action of unblocking)on the neurovascular unit of the patients with acute ischemic stroke(AIS)in terms of serological indicators so as to provide new ideas for the treatment of AIS.Methods Seventy subjects with AIS were randomly divided into an observation group(35 cases,1 case dropped out)and a control group(35 cases,4 cases dropped out).Patients in the control group were treated with conventional regimen.In the observation group,the bloodletting was operated,combined with the conventional treatment.Bloodletting was performed at Baihui(GV20),Sishencong(EX-HN1)and bilateral Erjian(EX-HN6),using He's qiangtong method of acupuncture,3 times a week and for 2 weeks.Before and after treatment,the scores of the national institute of health stroke scale(NIHSS),the modified Rankin scale(MRS),and the Barthel index were evaluated;and the serological levels of the serum brain-derived neurotrophic factor(BDNF),vascular endothelial growth factor(VEGF),glial fibrillary acidic protein(GFAP),neuron-specific enolase(NSE)and blood-brain barrier permeability-associated protein(S100βprotein)were detected in the two groups.Results After treatment,NIHSS score and MRS score were decreased(P＜0.01),and Barthel score was increased(P＜0.01)in both groups.NIHSS score of the observation group was lower than that of the control group(P＜0.01).Compared with those before treatment,the content of BDNF in both groups increased(P＜0.05),and VEGF content was elevated in the observation group(P＜0.05)after treatment.The total effective rate was 100％(34/34)in the observation group,higher than that(67.74％,21/31)in the control group(P＜0.01).Conclusion He's qiangtong method of acupuncture can promote the recovery of neurological deficits in AIS patients and effectively improve their motor function and the activity of daily living,which may be related to the reconstruction of neurovascular unit in the brain of AIS patients by increasing the levels of serological repair factors.关键词
贺氏强通法/放血/急性缺血性脑卒中/细胞因子Key words
He's qiangtong method of acupuncture/Bloodletting/Acute ischemic stroke/Cytokine引用本文复制引用
谢媛,付渊博,李彬,张帆,温雅丽,王少松,宋玉强,王璟霏,周菁,刘爽..贺氏强通法对急性缺血性脑卒中患者神经血管单元的修复作用[J].针刺研究,2024,49(11):1198-1204,7.基金项目
针灸神经调控北京市重点实验室项目(No.BZ0437) （No.BZ0437）
2021年度"扬帆"计划重点医学专业(重点扶持专业)—中西医结合康复项目(No.ZYLX202140) （重点扶持专业）
北京市科学技术委员会—首都临床特色诊疗技术研究及转化应用项目(No.Z221100007422078) （No.Z221100007422078）
