针刺研究2024，Vol.49Issue(11)：1205-1212,8.DOI:10.13702/j.1000-0607.20230547
基于神经元细胞周期重启探讨针灸防治阿尔茨海默病的机制
Research progress of mechanism of acupuncture and moxibustion on prevention and treatment of Alzheimer's disease based on the neuronal cell cycle re-entry
摘要
Abstract
Alzheimer's disease(AD)is the most common type of dementia.Studies have shown that neuronal cell cycle re-entry is an abnormal change in the early stage of AD,and it is also one of the key reasons for mediating neuronal death.The mechanism of acupuncture and moxibustion in treating AD may be related to the regulation of abnormal cell cycle.In this article,we reviewed the occurrence of AD neuronal cell cycle re-entry and its mediated cell death mechanism,listed the factors affecting neuronal cell cycle re-entry,explored the possible mechanism of acupuncture and moxibustion in preventing and treating AD by regulating AD cell cycle protein,AD neuronal cell cycle re-entry influencing factors(β-amyloid protein and Tau protein phosphorylation level,oxidative stress,brain-derived neurotrophic factor),the multi-target regulation of neuronal cell cycle re-entry,so as to provide reference for the application and research of acupuncture and moxibustion in preventing and treating AD.关键词
阿尔茨海默病/针刺/艾灸/神经元/细胞周期Key words
Alzheimer's disease/Acupuncture/Moxibustion/Neuron/Cell cycle引用本文复制引用
罗泳茵,单晓倩,宋京京,郝楠,赵岚..基于神经元细胞周期重启探讨针灸防治阿尔茨海默病的机制[J].针刺研究,2024,49(11):1205-1212,8.基金项目
国家自然科学基金项目(No.82074533) （No.82074533）
