中国临床药学杂志2024，Vol.33Issue(10)：721-725,5.DOI:10.19577/j.1007-4406.2024.10.001
应用蒙特卡罗模拟法优化中国儿童癫痫患者卡马西平给药方案
Monte Carlo simulation optimizes dosing regimens of carbamazepine for Chinese children with epilepsy
摘要
Abstract
AIM Using the Monte Carlo simulation(MCS)method in conjunction with pharmacokinetic/pharmacodynamic theory,to optimize the dosing regimen of carbamazepine(CBZ)for Chinese epileptic children with CYP1A2 gene polymorphism.METHODS Based on the published population pharmacokinetic data of CBZ in Chinese children with epilepsy,MCS method was used to predict the probability of target attainment(PTA)of CBZ steady-state blood concentration reaching the effective therapeutic concentration range under different dosing regimens.RESULTS When the CYP1A2 genotype of the pediatric patient was AA,the dosing regimen of CBZ at 8mg·kg-1 tid resulted in the highest PTA(80.14％).When the CYPIA2 genotype of the pediatric patient was CC/CA,the dosing regimen of 7 mg·kg-1 tid resulted in the highest PTA(80.71％),which was the optimal dosing scheme.Sensitivity analysis showed that after excluding the factor of dosing,genetic polymorphism was the main factor affecting the steady-state plasma concentration of CBZ.CONCLUSION The MCS method has optimized the dosing regimen of CBZ for epileptic children with different CYP1A2 genotypes,providing a basis for precision clinical medication strategies.关键词
卡马西平/蒙特卡罗模拟/儿童癫痫/稳态血药浓度/达标概率Key words
carbamazepine/Monte Carlo simulation/children with epilepsy/steady state concentration/probability of target attainment引用本文复制引用
李彦萍,杭永付,杨嘉永,陈方..应用蒙特卡罗模拟法优化中国儿童癫痫患者卡马西平给药方案[J].中国临床药学杂志,2024,33(10):721-725,5.基金项目
福建省自然科学基金(编号2020D031) （编号2020D031）
福建省卫生健康委员会中青年骨干项目(编号2020GGB053) （编号2020GGB053）
中国药学会-施维雅青年医院药学创新研究(编号CPA-B04-ZC-2022-001) （编号CPA-B04-ZC-2022-001）
