中国临床药学杂志2024，Vol.33Issue(10)：751-756,6.DOI:10.19577/j.1007-4406.2024.10.006
异甘草酸镁注射液致低钾血症的危险因素及风险预测模型
Risk factors and risk prediction model of hypokalemia induced by magnesium isoglycyrrhizinate injection
摘要
Abstract
AIM To investigate the risk factors of hypokalemia induced by magnesium isoglycyrrhizinate injection and establish a hypokalemia risk prediction model,so as to promote the safe use of magnesium isoglycyrrhizinate injection.METHODS The data of patients hospitalized from February to August 2023 who were receiving magnesium isoglycyrrhizinate injections were collected by retrospective study.The diagnosis of hypokalemia was based on serum potassium concentration＜3.5 mmol·L-1.A risk prediction model for hypokalemia was developed by analyzing potential risk factors using both univariate analysis and Logistic regression.Receiver operating characteristic(ROC)curves were used to evaluate the efficacy of each risk factor and the co-predictors.RESULTS A total of 300 hospitalized patients were included,among which 74 had hypokalemia,the incidence of hypokalemia was 24.67％.Univariate analysis showed that age,sex,single dose,tumor,and combined use of potassium diuretics and antibiotics increased the risk of adverse reactions of hypokalemia(P＜0.05).Multivariate Logistic regression analysis showed that gender,age and combined use of antibiotics had significant effects on serum potassium level(P＜0.05).The hypokalemia risk prediction model equation was established as Y=0.972×Xsex+0.031 ×Xage+0.813×Xcombined use of antibiotics-4.700,with the AUC value of 0.714 for the ROC curve.The Yoden index for age was 0.232,at the age of 62.5 years.CONCLUSION A full evaluation of blood potassium levels should be conducted for female patients who are using antibiotics in combination,particularly for those over 62.5 years old,prior to the administration of magnesium isoglycyrrhizinate injection.If hypokalemia arises,timely correction is necessary to enhance the safety profile of clinical medication.关键词
异甘草酸镁/低钾血症/危险因素/合并用药/药物不良反应Key words
magnesium isoglycyrrhizinate/hypokalemia/risk factor/drug combination/adverse drug reaction引用本文复制引用
黄嬿,沈杰,韩佳航,常昕楠,顾晨晨,姚亚敏,张伊婧..异甘草酸镁注射液致低钾血症的危险因素及风险预测模型[J].中国临床药学杂志,2024,33(10):751-756,6.基金项目
上海市进一步加快中医药传承创新发展三年行动计划[编号ZY(2021-2023)-0203-02] （2021-2023）
