中国临床药学杂志2024，Vol.33Issue(10)：757-760,4.DOI:10.19577/j.1007-4406.2024.10.007
碳酸锂在青少年精神障碍患者中的剂量校正浓度及其影响因素
Analysis of influencing factors of dose-related concentration of lithium carbonate in adolescent patients with mental disorders
摘要
Abstract
AIM To investigate the influencing factors of dose-related concentration(C/D)in adolescent patients with mental disorders treated with lithium carbonate,and to provide a reference for the safe use of lithium carbonate in the adolescent population and for individualized treatment.METHODS Retrospective study was employed to collect and analyze the medical records of 166 inpatients with adolescent mental disorders treated with lithium carbonate from June 2017 to December 2019.The study aimed to investigate the effects of age,gender,height,weight,dosage form,body surface area,and estimated glomerular filtration rate(eGFR)on lithium carbonate C/D.RESULTS There was a negative correlation between body surface area and lithium carbonate C/D(β=-0.32,P＜0.001).There was no statistically significant correlation with dosage form,height,weight,or eGFR(P＞0.05).The regression equation of the model was C/D=1.26-0.32×body surface area,and the explanatory power of this linear regression model for C/D was 12％(F=22.45,P＜0.001).CONCLUSION Body surface area can affect lithium carbonate C/D in adolescent mental disorders.In clinical practice,for adolescent patients with lower body surface area,attention should be paid to the amount of lithium carbonate,and the monitoring of blood lithium concentration should be strengthened to ensure the safety of patients.关键词
青少年/精神障碍/碳酸锂/剂量校正浓度/影响因素Key words
adolescent/mental disorders/lithium carbonate/dose-related concentration/influencing factor引用本文复制引用
李培福,胡晓华,冯映映..碳酸锂在青少年精神障碍患者中的剂量校正浓度及其影响因素[J].中国临床药学杂志,2024,33(10):757-760,4.基金项目
武汉市卫生计生委科研计划资助项目(编号WX19Z28) （编号WX19Z28）
武汉市卫生计生委科研计划资助项目(编号WG20Q01) （编号WG20Q01）
