中国临床药学杂志2024，Vol.33Issue(10)：761-764,4.DOI:10.19577/j.1007-4406.2024.10.008
复方黄柏液涂剂联合甲硝唑凝胶治疗细菌性阴道炎的临床疗效
Efficacy and safety of compound Huangbai liquid coating agent combined with metronidazole gel in the treatment of bacterial vaginitis
韩知言 1王颖 1杨雪 1刘冰洁 1孔庆军1
作者信息
- 1. 中国人民解放军东部战区总医院保健科,南京 210000
- 折叠
摘要
Abstract
AIM To explore the clinical effect of compound Huangbai liquid coating agent combined with metronidazole gel in the treatment of bacterial vaginitis.METHODS A total of 120 patients diagnosed with bacterial vaginitis at our hospital from January 2022 to January 2023 were divided into control group and observation group by random number table method,with 60 patients in each group.The control group was treated with vaginal administration of metronidazole gel,while the observation group was treated with vaginal administration of metronidazole gel combined with compound Huangbai liquid coating agent in sitz bath,with a course of 7 days.After the course of treatment,the vaginal flora diversity,flora density,vaginal pH value and sex hormone level of 2 groups were detected and compared,and the clinical efficacy and safety of 2 groups were evaluated.RESULTS The total effective rate in the observation group was significantly higher than that in the control group(98.33％vs 88.33％,P＜0.05).The vaginal pH value,flora diversity and flora density in the observation group were significantly better than those in the control group(P＜0.05).The levels of testosterone,progesterone and estradiol in 2 groups were significantly higher after treatment(P＜0.05),and levels in the observation group were significantly higher than those in the control group(P＜0.05).There were no adverse drug reactions in both groups.CONCLUSION Compound Huangbai liquid coating agent combined with metronidazole gel is effective and safe in the treatment of bacterial vaginitis,which can effectively increase the level of sex hormones and improve the acid-base environment of vagina.关键词
复方黄柏液涂剂/甲硝唑凝胶/细菌性阴道炎/菌群密集度/菌群多样性/性激素Key words
compound Huangbai liquid coating agent/metronidazole gel/bacterial vaginitis/flora density/flora diversity/sex hormone引用本文复制引用
韩知言,王颖,杨雪,刘冰洁,孔庆军..复方黄柏液涂剂联合甲硝唑凝胶治疗细菌性阴道炎的临床疗效[J].中国临床药学杂志,2024,33(10):761-764,4.
