中国临床药学杂志2024，Vol.33Issue(10)：765-769,5.DOI:10.19577/j.1007-4406.2024.10.009
己酮可可碱对脑梗死合并老年衰弱综合征患者神经和认知功能障碍的影响
Effect of pentoxifylline on neurological and cognitive dysfunction in elderly patients with cerebral infarction-related frailty
摘要
Abstract
AIM To explore the effect of pentoxifylline on improving neurological and cognitive dysfunction in elderly patients with cerebral infarction-related frailty.METHODS A total of 160 elderly patients with cerebral infarction-related frailty admitted to our hospital from January 2020 to January 2022 were randomly divided into control group(80 patients,using conventional basic treatment)and study group(80 patients,using pentoxifylline based on conventional basic treatment).The clinical data of patients were collected.The improvement effect of neurological and cognitive dysfunction and the incidence of adverse reactions were compared between 2 groups.RESULTS Before treatment,there were no significant differences between 2 groups in the neurological function defect score(NIHSS),score of activity of daily living(ADL),regional cerebral blood flow(rCBF),mini mental status examination(MMSE)and Montreal cognitive assessment(MoCA)(all P＞0.05).After treatment,the NIHSS scores of the elderly patients with frailty in 2 groups decreased obviously(P＜0.05),while the ADL score,rCBF score,MMSE score,and MoCA score increased obviously(all P＜0.05).Changes in the above indexes in the study group were significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between 2 groups(P＞0.05).CONCLUSION Pentoxifylline,which has a definite effect on the treatment of elderly patients with cerebral infarction-related frailty,can significantly improve the neurological and cognitive dysfunction of patients.Moreover,it is safe and worthy of promotion.关键词
脑梗死/老年衰弱综合征/己酮可可碱/神经功能/认知功能Key words
cerebral infarction/senile frailty/pentoxifylline/neurological function/cognitive function引用本文复制引用
李净兵,王会军,王少颖,赵璨,王莉迪,曹玉娇..己酮可可碱对脑梗死合并老年衰弱综合征患者神经和认知功能障碍的影响[J].中国临床药学杂志,2024,33(10):765-769,5.基金项目
河北省医学科学研究课题计划项目(编号20200703) （编号20200703）
