中国脑血管病杂志2024，Vol.21Issue(10)：693-699,7.DOI:10.3969/j.issn.1672-5921.2024.10.008
水通道蛋白4在缺血性卒中后的作用及调控机制研究进展
Recent advances in the role and regulatory mechanisms of aquaporin 4 in ischemic stroke
摘要
Abstract
As the main water channel expressed in the brain,aquaporin 4(AQP4)has been implicated in the pathological process of ischemic stroke.After ischemic stroke,the expression,phosphorylation and polarity distribution of AQP4 are affected by the process of transcription and post-translational modification.The paper summarized the basic structure,physiological function,dynamic expression changes and mechanisms of AQP4 in this review,specifically discussing the role of AQP4 in cerebral edema,blood-brain barrier permeability and neuroinflammation after ischemic stroke,offering an up-to-date perspective on further effective therapeutic strategies for ischemic stroke.关键词
水通道蛋白质4/缺血性卒中/脑水肿/血-脑屏障/神经胶质/神经炎症/综述Key words
Aquaporin 4/Ischemic stroke/Brain edema/Blood-brain barrier/Neuroglia/Neuroinflammation/Review引用本文复制引用
伍晓梅,彭林辉,李孔平,左夏林..水通道蛋白4在缺血性卒中后的作用及调控机制研究进展[J].中国脑血管病杂志,2024,21(10):693-699,7.基金项目
国家自然科学基金(81971233) （81971233）
广州医科大学科研能力提升项目(广医发[2023]16号) （广医发[2023]16号）
