中国脑血管病杂志2024，Vol.21Issue(10)：700-707,8.DOI:10.3969/j.issn.1672-5921.2024.10.009
Ras同源基因家族蛋白A/Rho相关卷曲螺旋蛋白激酶信号通路调控缺血性卒中的研究进展
Progress on the regulation of RhoA/ROCK signaling pathway in ischemic stroke
摘要
Abstract
Ras homolog gene family member A(RhoA)is a small GTPase protein.Rho-associated coiled-coil forming protein kinase(ROCK)can be activated during the occurrence and development of ischemic stroke.RhoA/ROCK signaling pathway is an important regulatory factor in the pathological process of ischemic stroke,and regulation of this signaling pathway has become a research focus in promoting neuronal recovery and improving cerebral ischemia/reperfusion injury after ischemic stroke.However,only Fasudil is currently available as a RhoA/ROCK inhibitor.The rest is still in the stage of research and development or clinical trials,and has broad research prospects.In this paper,the regulatory role and mechanism of RhoA/ROCK signaling pathway in ischemic stroke were analyzed,and the application of inhibitors and regulatory drugs were described,aiming to provide new ideas for the prevention and treatment of ischemic stroke.关键词
缺血性卒中/RhoA GTP结合蛋白质/Rho相关激酶类/RhoA/ROCK信号通路/抑制剂/综述Key words
Ischemic stroke/RhoA GTP-binding protein/Rho-associated kinases/RhoA/ROCK signaling pathway/Inhibitor/Review引用本文复制引用
张展,姜德龙,王庆谚,王鹏琴..Ras同源基因家族蛋白A/Rho相关卷曲螺旋蛋白激酶信号通路调控缺血性卒中的研究进展[J].中国脑血管病杂志,2024,21(10):700-707,8.基金项目
国家自然科学基金(82004229) （82004229）
沈阳市中医药专家学术经验继承项目(A10402) （A10402）
