中国实用外科杂志2024，Vol.44Issue(10)：1109-1114,6.DOI:10.19538/j.cjps.issn1005-2208.2024.10.06
胃癌免疫治疗研究进展
Advances and reflections on neoadjuvant immunotherapy for advanced gastric cancer
摘要
Abstract
Currently,chemotherapy combined with immune checkpoint inhibitors(ICIs)has become one of the important treatments for advanced gastric cancer or adenocarcinoma of esophagogastric junction.However,the effectiveness of this ap-proach in locally advanced gastric cancer has still not been val-idated by higher-level studies.The combination of molecular markers and personalised tests may be an effective means of screening the population for the benefits of immunotherapy in gastric cancer;The neoadjuvant immunotherapy regimen should take into account the specific type of tumour,molecular characteristics,and the patient's overall health status.Rou-tine evaluation after 2-4 cycles of neoadjuvant therapy com-bined with multidisciplinary team discussion can grasp the best timing during the whole treatment process and maintain the best interests of patients;The evaluation of the efficacy of neoadjuvant immunotherapy requires comprehensive judg-ment,and imaging and pathological evaluation are still subject to great controversy;The surgical interval of 4-6 weeks after neoadjuvant immunotherapy may be the optimal timing of sur-gery.The choice of surgery should take into account the loca-tion and size of the tumour,the patient's overall health status,and technical feasibility.Careful management and effective in-tervention of adverse events(IrAEs)during neoadjuvant immu-notherapy will help to improve the patient's outcome,and cli-nicians should closely monitor the patient's physical response throughout the course of the treatment and adjust the treatment regimen accordingly to ensure the best-balanced outcome.关键词
胃癌/免疫检查点抑制剂/新辅助治疗Key words
gastric cancer/immune checkpoint inhibitors/neoadjuvant therapy分类
医药卫生引用本文复制引用
徐泽宽,李沣员,吴昊..胃癌免疫治疗研究进展[J].中国实用外科杂志,2024,44(10):1109-1114,6.基金项目
国家自然科学基金项目(No.81871946,No.82072708) （No.81871946,No.82072708）
中国国家科学技术基础研究专项基金项目(No.2019FY101104) （No.2019FY101104）
江苏省高等教育机构重点学科建设项目(JX10231801) （JX10231801）
江苏省重点学科(普通外科学)项目(No.ZDXKA2016005) （普通外科学）
南京医科大学第一附属医院创新研究项目(No.PAPD) （No.PAPD）
