中国实用外科杂志2024，Vol.44Issue(10)：1129-1133,5.DOI:10.19538/j.cjps.issn1005-2208.2024.10.10
免疫治疗时代Ⅳ期胃癌转化治疗方案选择
Selection of transformation treatment plans for stage Ⅳ gastric cancer in the era of immunotherapy
摘要
Abstract
The transformation therapy for stage Ⅳ gastric cancer has become a current research hotspot.For patients with advanced gastric cancer undergoing conversion therapy,RO resection surgery should be attempted;For tumor lesions that are difficult to cure after evaluation,it is recommended to continue drug treatment and avoid palliative resection of R1 or R2 as much as possible.For stage Ⅳ gastric cancer patients with combined peritoneal metastasis,in addition to systemic chemotherapy,the combination of intraperitoneal infusion chemotherapy and immunotherapy has also become a research focus.At present,most conclusions are mainly based on small sample retrospective studies,and some studies have not distinguished between conversion therapy and neoadjuvant therapy.Therefore,there is an urgent need for large-scale prospective randomized controlled trials to further validate.In addition,advanced gastric cancer has high heterogeneity and significant individual differences.The molecular pathological characteristics between primary and metastatic lesions vary,requiring a deep understanding of epigenetics,genomics,and proteomics information in gastric cancer to guide individualized treatment for patients.关键词
胃癌/转化治疗/腹腔灌注/免疫治疗Key words
gastric cancer/conversion therapy/intraperitone-al infusion/immunotherapy分类
医药卫生引用本文复制引用
王权,李爽..免疫治疗时代Ⅳ期胃癌转化治疗方案选择[J].中国实用外科杂志,2024,44(10):1129-1133,5.基金项目
北京市希思科临床肿瘤学研究基金会项目(No.Y-MSDPU2021-0281) （No.Y-MSDPU2021-0281）
