中国药理学与毒理学杂志2024，Vol.38Issue(11)：846-858,13.DOI:10.3867/j.issn.1000-3002.2024.11.006
胰高血糖素样肽1受体激动剂在药物成瘾中的作用研究进展
Research advance in roles of glucagon-like peptide-1 receptor agonists in drug addiction
摘要
Abstract
Drug addiction is a major medical and social issue globally,but there is still a lack of ideal clinical treatments.Glucagon-like peptide-1(GLP-1),a key gut-brain peptide,and its receptor agonists have been approved for the treatment of type 2 diabetes and obesity.In recent years,the role of GLP-1 receptor agonists in combating drug addiction has received increasing attention.Based on an overview of the GLP-1 system and its receptor agonist,this article reviews the role of GLP-1 receptor agonists in drug addiction at both the nonclinical and clinical levels by focusing on addictive psychoactive substances(including alcohol,tobacco,cocaine,opioids,and amphetamines).Future developments are also predicted to provide new clues to the mechanism of drug addiction and development of therapeutic drugs.关键词
胰高血糖素样肽1/胰高血糖素样肽1受体激动剂/药物成瘾Key words
glucagon-like peptide-1/glucagon-like peptide-1 receptor agonists/drug addiction分类
医药卫生引用本文复制引用
卢关伊,邓青梅,吴宁,李锦..胰高血糖素样肽1受体激动剂在药物成瘾中的作用研究进展[J].中国药理学与毒理学杂志,2024,38(11):846-858,13.基金项目
国家重点研发计划(2023YFC3304201) （2023YFC3304201）
国家自然科学基金(82373853) （82373853）
国家自然科学基金(81973303) National Key Research and Development Program(2023YFC3304201) （81973303）
National Natural Science Foundation of China(82373853) （82373853）
and National Natural Science Foundation of China(81973303) （81973303）
