中国药理学与毒理学杂志2024，Vol.38Issue(11)：880-886,7.DOI:10.3867/j.issn.1000-3002.2024.11.009
纳米氧化锌的肺毒性及机制研究进展
Research progress in pulmonary toxicity and mechanisms of zinc oxide nanoparticles
摘要
Abstract
Zinc oxide nanoparticles(ZnO NPs)have been gradually introduced into people's lives due to their excellent properties.In daily contact,ZnO NPs can enter the human body in a variety of ways and accumulate in tissues and organs.Inhalation is an important means by which ZnO NPs enter the human body and deposit in lungs.Studies have shown that exposure of lungs to ZnO NPs will cause a range of negative effects.The mechanism of pulmonary toxicity induced by ZnO NPs is related to Zn2+release,oxidative stress,DNA damage,autophagy,inflammation and pulmonary surfactant dysfunction.This paper reviews the pulmonary toxicity and mechanisms of ZnO NPs,and summarizes the prevention and treatment strategies,which provides scientific basis for safer use of nanomaterials,and potential intervention strategies for the prevention and treatment of nanotoxicity.关键词
纳米氧化锌/肺毒性/呼吸暴露/毒性机制Key words
zinc oxide nanoparticles/pulmonary toxicity/respiratory exposure/mechanism of toxicity分类
医药卫生引用本文复制引用
王皇斌,熊闽,黄莎莎,黄丽端,许秋凤,陈淑珍..纳米氧化锌的肺毒性及机制研究进展[J].中国药理学与毒理学杂志,2024,38(11):880-886,7.基金项目
福建省自然科学基金(2021J01343) （2021J01343）
福建省大学生创新创业训练计划(S202212631003) The General Project of Fujian Provincial Natural Science Foundation(2021J01343) （S202212631003）
and the Innova-tion and Entrepreneurship Training Program for Undergraduates of Fujian Province(S202212631003) （S202212631003）
