中国医学创新2024，Vol.21Issue(28)：1-6,6.DOI:10.3969/j.issn.1674-4985.2024.28.001
牛碱性成纤维细胞生长因子联合脱细胞真皮基质修复深Ⅱ度烧伤创面的临床研究
Clinical Study on Bovine Basic Fibroblast Growth Factor Combined with Acellular Dermal Matrix for Repairing Deep Second Degree Burn Wounds
摘要
Abstract
Objective:To observe the clinical effect of Bovine Basic Fibroblast Growth Factor combined with acellular dermal matrix(ADM)in repairing wound surface of deep second degree burn.Method:A total of 120 patients with deep second degree burn treated in Jiujiang NO.1 People's Hospital from January to December 2023 were selected and divided into group A,group B and group C according to random number table method,40 cases in each group.Group A was coated with Bovine Basic Fibroblast Growth Factor Gel and ADM after debridement,group B was directly covered with ADM after debridement,and group C only Bovine Basic Fibroblast Growth Factor Gel was external applied after debridement.The wound condition(wound healing,wound volume and later surgery rate),scar condition[Vancouver scar scale(VSS),incidence of pigmentation],inflammatory factors[white blood cell(WBC)count,hypersensitive C reactive protein(hs-CRP)and interleukin-6(IL-6)]of three groups were compared,and the clinical efficacy and incidence of adverse reactions were counted.Result:The wound healed completely after 3 months,the incidence of pigmentation in group A,and the later surgery rate after 30 days of treatment in group A were lower than those in group B and group C,the wound volume after 7,14 and 21 days of treatment were lower than those in group B and group C,and the wound healing were significantly higher than those in group B and group C(P<0.05).After 21 d of treatment,the levels of WBC,hs-CRP and IL-6 in group A were significantly lower than those in group B and group C(P<0.05).The total clinical effective rate of group A was significantly higher than that of group B and group C(P<0.05).There was no significant difference in the incidence of adverse reactions among three groups(字2=1.208,P=0.547).Conclusion:Bovine Basic Fibroblast Growth Factor Gel combined with ADM has a significant effect in repairing wound surface of deep second degree burn,and has positive improve effects on wound healing,scar condition,pigmentation and inflammatory factors of patients,with high safety.关键词
牛碱性成纤维细胞生长因子凝胶/脱细胞真皮基质/深Ⅱ度烧伤/烧伤创面/瘢痕/炎症因子Key words
Bovine Basic Fibroblast Growth Factor Gel/Acellular dermal matrix/Deep second degree burn/Burn wound surface/Scar/Inflammatory factors引用本文复制引用
曹青,何霞飞..牛碱性成纤维细胞生长因子联合脱细胞真皮基质修复深Ⅱ度烧伤创面的临床研究[J].中国医学创新,2024,21(28):1-6,6.基金项目
江西省卫生健康委科技计划项目(202311456) （202311456）
