摘要
Abstract
Objective:To investigate the clinical efficacy of Edaravone Dexborneol and Danhong Injection in the treatment of patients with acute cerebral infarction(ACI)and their effects on hemorheology and serum miR-34c levels.Method:Between August 2021 and February 2023,104 ACI patients admitted to the Third Affiliated Hospital of Gannan Medical University were selected as the study subjects and randomly divided into the single group and the combination group.Both groups received routine treatment,and on the basis of routine treatment,the single group received Danhong Injection treatment while the combination group received Edaravone Dexborneol and Danhong Injection treatment.Both groups were treated for 2 weeks.The clinical efficacy,neurologic function,activities of daily living,hemorheology indexes before and after treatment,and adverse reactions were observed in the patients.Blood samples were collected to detect the changes in serum superoxide dismutase(SOD),high-sensitivity C reactive protein(hs-CRP)and miR-34c levels.Result:The total effective rate of the combination group after treatment was 90.38%,significantly higher than 75.00%of the single group,the difference between two groups was statistically significant(P<0.05).After 1 week and 2 weeks of treatment,the NIHSS scores,various indicators of hemorheology and hs-CRP levels in both groups were significantly reduced,and those of the combination group were significantly lower than those of the single group(P<0.05);the Barthel index score,serum SOD and miR-34c levels were significantly increased,and those of the combination were significantly higher than those of the single group(P<0.05).There were no statistically significant differences in the incidences of adverse reactions between two groups(P>0.05).Conclusion:The combination of Edaravone Dexborneol and Danhong Injection in the treatment of patients with ACI can improve the clinical efficacy and activities of daily living,improve neurologic function and hemorheology,and upregulate serum miR-34c levels to inhibit inflammatory responses.关键词
依达拉奉右莰醇/丹红注射液/急性脑梗死/血液流变学/miR-34cKey words
Edaravone Dexborneol/Danhong Injection/Acute cerebral infarction/Hemorheology/miR-34c
