摘要
Abstract
Pre-eclampsia(PE)is a common pregnancy complication that seriously threatens the health of both mother and baby.The main clinical manifestations are hypertension,edema,and proteinuria,which can lead to multiple organ dysfunction,disseminated intravascular coagulation,placental abruption,fetal growth restriction,and other adverse perinatal outcomes.It is one of the main reasons for the increase in maternal and neonatal mortality rates.The basic pathological and physiological changes are systemic small vessel spasm and endothelial injury,but its pathogenesis is not fully understood.Relevant theories mainly include insufficient remodeling of uterine spiral arterioles,excessive activation of inflammatory immunity,damage to endothelial cells,genetic factors,etc.It is particularly important to strengthen screening for PE in order to reduce the occurrence of adverse pregnancy outcomes.Based on relevant studies,this paper analyzes the role of insulin-like growth factor-1,placental growth factor,soluble fms-like tyrosine kinase-1,soluble fms-like tyrosine kinase-1/placental growth factor,pregnance-associated plasma protein A,serum placental protein 13 and other factors in evaluating the pathogenesis and severity of the disease.Detecting factors related to high-risk pregnant women during pregnancy can help detect,treat,and prevent PE early,which is of great significance in reducing maternal and infant mortality rates.关键词
妊娠/子痫前期/预测因子/筛查Key words
Pregnancy/Pre-eclampsia/Predictive factor/Screening
