中国医学创新2024，Vol.21Issue(29)：1-5,5.DOI:10.3969/j.issn.1674-4985.2024.29.001
左乙拉西坦联合咪达唑仑在癫痫持续状态患者中的应用效果
Application Effect of Levetiracetam Combined with Midazolam in Patients with Status Epilepticus
摘要
Abstract
Objective:To investigate the effect of Levetiracetam combined with Midazolam in patients with status epilepticus(SE).Method:A total of 90 SE patients admitted to Yichun People's Hospital from May 2020 to September 2023 were selected and divided into two groups according to random number table method,with 45 cases in each group.The control group was treated with Midazolam,and the observation group was treated with Levetiracetam on the basis of the control group,the follow-up was 3 months.The therapeutic effect and safety of the two groups were compared.Result:The total effective rate of observation group was higher than that of control group(P<0.05).After 3 months of treatment,the performance IQ(PIQ),verbal IQ(VIQ)and full IQ(FIQ)scores of the observation group were(97.51±6.42),(98.44±6.89)and(104.85±7.89)scores,respectively,which were higher than(91.37±6.32),(92.18±6.67)and(95.63±6.52)scores in the control group,the differences were statistically significant(P<0.05).After 3 months of treatment,the levels of immunoglobulin M(IgM)and immunoglobulin A(IgA)in the observation group were(1.32±0.24)and(1.78±0.28)g/L,respectively,which were higher than(1.13±0.22)and(1.45±0.26)g/L in the control group,the differences were statistically significant(P<0.05).After 3 months of treatment,the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),neuron-specific enolase(NSE)and high mobility group protein B1(HMGB1)in the observation group were(12.58±2.05)pg/mL,(16.29±2.18)μg/L and(49.36±5.17)μg/L,(3.42±0.41)ng/mL,respectively,which were lower than(14.87±2.12)pg/mL,(20.62±2.25)μg/L,(54.36±5.23)μg/L,(4.02±0.46)ng/mL in the control group,the EEG state of the observation group was better than that of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of Levetiracetam and Midazolam can enhance the efficacy of SE patients,correct the abnormality of immunoglobulin,reduce the levels of serum IL-6,TNF-α,NSE and HMGB1,and improve the EEG state,which is safe and reliable.关键词
癫痫持续状态/左乙拉西坦/咪达唑仑/认知功能/免疫球蛋白Key words
Status epilepticus/Levetiracetam/Midazolam/Cognitive function/Immunoglobulin引用本文复制引用
漆苏,李晶,彭向玉,陈文碧,朱学鹏,袁俊..左乙拉西坦联合咪达唑仑在癫痫持续状态患者中的应用效果[J].中国医学创新,2024,21(29):1-5,5.基金项目
江西省卫生健康委科技计划项目(202342220) （202342220）
