摘要
Abstract
Objective:To explore the effects of Ticagrelor combined with percutaneous coronary intervention(PCI)on cardiac function and vascular endothelial function in patients with acute myocardial infarction(AMI).Method:A total of 102 AMI patients undergoing PCI admitted to the Department of Cardiology of Yichun Second People's Hospital from January 2021 to January 2023 were selected as the study objects,and were divided into control group and observation group according to random number table method,with 51 cases in each group.On the basis of routine treatment and PCI,the control group received Aspirin Enteric-coated Tablets+Clopidogrel Hydrogen Sulphate Tablets,and the observation group received Aspirin Enteric-coated Tablets+Ticagrelor Tablets.Cardiac function[left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)and left ventricular ejection fraction(LVEF)],vascular endothelial function[endothelin-1(ET-1),nitric oxide(NO),prostacycline I2(PGI2),thromboxane B2(TXB2)]and serum myocardial markers[creatine kinase isoenzyme(CK-MB),cardiac troponin I(cTnI),N-terminal brain natriuretic peptide precursor(NT-proBNP)]levels and major adverse cardiovascular events(MACE)were compared between the two groups.Result:After treatment,LVEDD and LVESD in both groups were lower than those before treatment,and LVEF were higher than those before treatment,LVEDD and LVESD in the observation group were lower than those in the control group,while LVEF was higher than that in the control group(P<0.05).After treatment,ET-1 and TXB2 in both groups were lower than those before treatment,while NO and PGI2 were higher than those before treatment,ET-1 and TXB2 in the observation group were lower than those in the control group,and NO and PGI2 were higher than those in the control group(P<0.05).After treatment,CK-MB,cTnI,and NT-proBNP in both groups were lower than those before treatment,and the levels of CK-MB,cTnI,and NT-proBNP in the observation group were lower than those in the control group(P<0.05).The incidence of MACE in the observation group was lower than that in the control group(P<0.05).Conclusion:Ticagrelor combined with PCI can significantly improve cardiac function and vascular endothelial function in patients with AMI,and reduce myocardial injury indicators and the risk of MACE.关键词
替格瑞洛/经皮冠状动脉介入治疗/急性心肌梗死/心功能/血管内皮功能Key words
Ticagrelor/Percutaneous coronary intervention/Acute myocardial infarction/Cardiac function/Vascular endothelial function
