摘要
Abstract
Objective:To analyze the effects of percutaneous transhepatic cholangioscopic lithotripsy(PTCSL)versus laparoscopic common bile duct exploration(LCBDE)on serum inflammatory factors and liver function in patients with complex intrahepatic bile duct stones.Method:A total of 100 patients with complex intrahepatic bile duct stones treated at Yichun Xinjian Hospital from February 2020 to August 2023 were selected for this study.They were divided into cholangioscopy group(n=50)and laparoscopy group(n=50)by computer random numbering method.The cholangioscopy group received PTCSL,while the laparoscopy group underwent LCBDE.The preoperative and postoperative serum levels of inflammatory markers[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and C reactive protein(CRP)]and liver function indicators[aspartate aminotransferase(AST),alanine aminotransferase(ALT),and gamma-glutamyl transferase(γ-GT)]were compared between the two groups,the therapeutic effect,the occurrence of complications and the recurrence of six months after operation were recorded in the two groups.Result:3 d after surgery,the levels of IL-6,TNF-α,CRP,AST,ALT and γ-GT in two groups were lower than those 1 d before surgery,and those of the laparoscopy group were lower than those of the cholangioscopy group,the differences were statistically significant(P<0.05).The operation time and hospital stay of laparoscopy group were shorter than those of cholangioscopy group,and the intraoperative blood loss was less than that of cholangioscopy group,the differences were statistically significant(P<0.05).The total clinical effective rate of laparoscopy group was higher than that of cholangioscopy group(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).The recurrence rate of laparoscopy group was lower than that of cholangioscopy group(P<0.05).Conclusion:LCBDE can not only reduce the inflammation level of patients,improve liver function,but also promote rapid recovery of patients.关键词
经皮经肝穿刺胆道镜取石术/腹腔镜胆总管探查取石术/复杂肝内胆管结石/炎症因子/肝功能Key words
Percutaneous transhepatic cholangioscopic lithotripsy/Laparoscopic common bile duct exploration/Complex intrahepatic bile duct stones/Inflammatory factor/Liver function
