摘要
Abstract
Objective:To investigate the effect of intratracheal drip of pulmonary surfactant combined with ventilator on neonatal respiratory distress syndrome and its influence on oxygenation function and pulmonary gas exchange function.Method:A total of 80 children with neonatal respiratory distress syndrome admitted to Mudan People's Hospital of Heze City from June 2020 to June 2023 were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group was treated with ventilator,and the observation group was treated with intratracheal drip of Calf Pulmonary Surfactant on the basis of the control group.The total effective rate,ventilator application time and hospital stay,before and after treatment of blood gas analysis indexes[arterial partial pressure of oxygen(PaO2)and arterial partial pressure of carbon dioxide(PaCO2)],oxygenation function indexes[oxygenation index(OI)and respiratory index(RI)]and pulmonary gas exchange indexes[alveolar-arterial oxygen partial pressure difference(PA-aDO2)and diffusion index]of two groups were compared.Result:The total effective rate of the observation group was significantly higher than that of the control group,and the ventilator application time and hospital stay were significantly shorter than those of the control group,the differences were statistically significant(P<0.05).There were no statistical significance in blood gas analysis indexes,oxygenation function indexes and pulmonary gas exchange indexes between two groups before treatment(P>0.05).After 12,24 and 48 h of treatment,PaO2,OI and diffusion index in the observation group were significantly higher than those in the control group,and PaCO2,RI and PA-aDO2 were significantly lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The effect of intratracheal drip of pulmonary surfactant combined with ventilator in the treatment of neonatal respiratory distress syndrome is better,and can significantly improve the oxygenation function and pulmonary gas exchange function of the children.关键词
气管内滴入肺表面活性物质/新生儿呼吸窘迫综合征/氧合功能/肺换气Key words
Intratracheal drip of pulmonary surfactant/Neonatal respiratory distress syndrome/Oxygenation function/Pulmonary gas exchange
